SMYD2 Inhibition Downregulates TMPRSS2 and Decreases SARS-CoV-2 Infection in Human Intestinal and Airway Epithelial Cells

SMYD2 Inhibition Downregulates TMPRSS2 and Decreases SARS-CoV-2 Infection in Human Intestinal and Airway Epithelial Cells

The COVID-19 pandemic caused by SARS-CoV-2 has lasted for more than two years. Despite the presence of very effective vaccines, the number of virus variants that escape neutralizing antibodies is growing. Thus, there is still a need for effective antiviral treatments that target virus replication in...

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Bibliographic Details
Main Authors: Yu-Qiang Yu, Alexandra Herrmann, Veronika Thonn, Arne Cordsmeier, Markus F. Neurath, Armin Ensser, Christoph Becker
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
SMYD2
TMPRSS2
SARS-CoV-2
COVID-19
BAY598
AZ505
Online Access:https://www.mdpi.com/2073-4409/11/8/1262

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