Elevated Bile Acid Is Associated with Worsened Impaired Glucose Homeostasis in Pancreatic Ductal Adenocarcinoma Patients with Extrahepatic Cholestasis through Increased Hepatic Insulin Clearance

Elevated Bile Acid Is Associated with Worsened Impaired Glucose Homeostasis in Pancreatic Ductal Adenocarcinoma Patients with Extrahepatic Cholestasis through Increased Hepatic Insulin Clearance

Background: Patients after pancreaticoduodenectomy (PD) showed improved glucose tolerance. Evidence for the effect of extrahepatic cholestasis on impaired glucose homeostasis secondary to ductal adenocarcinoma of the pancreatic head is limited. Methods: In this prospective cross-sectional study, 50...

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Bibliographic Details
Main Authors: Jie Yang, Chunlu Tan, Zhenjiang Zheng, Xing Wang, Xubao Liu, Yonghua Chen
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Journal of Clinical Medicine
Subjects:
pancreaticoduodenectomy
pancreatic ductal adenocarcinoma
extrahepatic cholestasis
impaired glucose homeostasis
bile acid
hepatic insulin clearance
Online Access:https://www.mdpi.com/2077-0383/12/6/2352

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https://www.mdpi.com/2077-0383/12/6/2352

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