Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral head
Yong-Bin Yue,1,2 Xin Liu,2 Biao-Fang Wei2 1Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 2Department of Orthopedics, Linyi People’s Hospital, Linyi, Shandong Province, People’s Republic of China Objective: Decreased adiponectin (APN) levels have been de...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-10-01
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| Series: | Journal of Pain Research |
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| Online Access: | https://www.dovepress.com/attenuated-serum-adiponectin-levels-are-associated-with-disease-severi-peer-reviewed-article-JPR |
| _version_ | 1818453569486979072 |
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| author | Yue YB Liu X Wei BF |
| author_facet | Yue YB Liu X Wei BF |
| author_sort | Yue YB |
| collection | DOAJ |
| description | Yong-Bin Yue,1,2 Xin Liu,2 Biao-Fang Wei2 1Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 2Department of Orthopedics, Linyi People’s Hospital, Linyi, Shandong Province, People’s Republic of China Objective: Decreased adiponectin (APN) levels have been detected in patients with osteonecrosis of the femoral head (ONFH). The scope of this study was aimed to explore the relationship between serum APN levels and disease severity in nontraumatic ONFH patients.Patients and methods: Ninety two nontraumatic ONFH patients and 92 healthy controls were enrolled for this study following the estimation of sample size. Serum APN concentrations were examined by enzyme-linked immunosorbent assay (ELISA). The radiographic progression was determined by Ficat grading system. The clinical severity was evaluated by visual analog scale (VAS), Harris hip scores (HSSs) and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) scores.Results: Serum APN levels were significantly lower in ONFH patients than in healthy controls. Serum APN levels were significantly lower in patients with Ficat stage 4 ONFH than in patients with stage 3 ONFH, and APN levels in patients with stage 3 were lower compared with stage 2. Serum APN levels were negatively correlated with the Ficat grading system. In addition, serum APN levels were also negatively related to VAS and WOMAC scores and positively associated with HSSs.Conclusion: Decreased serum APN levels may reflect disease severity of nontraumatic ONFH. Keywords: adiponectin, radiological severity, symptomatic severity, nontraumatic osteonecrosis of the femoral head |
| first_indexed | 2024-12-14T21:41:04Z |
| format | Article |
| id | doaj.art-a078bc30dece477ba23695d6d1712b58 |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-12-14T21:41:04Z |
| publishDate | 2017-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-a078bc30dece477ba23695d6d1712b582022-12-21T22:46:28ZengDove Medical PressJournal of Pain Research1178-70902017-10-01Volume 102387239334978Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral headYue YBLiu XWei BFYong-Bin Yue,1,2 Xin Liu,2 Biao-Fang Wei2 1Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 2Department of Orthopedics, Linyi People’s Hospital, Linyi, Shandong Province, People’s Republic of China Objective: Decreased adiponectin (APN) levels have been detected in patients with osteonecrosis of the femoral head (ONFH). The scope of this study was aimed to explore the relationship between serum APN levels and disease severity in nontraumatic ONFH patients.Patients and methods: Ninety two nontraumatic ONFH patients and 92 healthy controls were enrolled for this study following the estimation of sample size. Serum APN concentrations were examined by enzyme-linked immunosorbent assay (ELISA). The radiographic progression was determined by Ficat grading system. The clinical severity was evaluated by visual analog scale (VAS), Harris hip scores (HSSs) and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) scores.Results: Serum APN levels were significantly lower in ONFH patients than in healthy controls. Serum APN levels were significantly lower in patients with Ficat stage 4 ONFH than in patients with stage 3 ONFH, and APN levels in patients with stage 3 were lower compared with stage 2. Serum APN levels were negatively correlated with the Ficat grading system. In addition, serum APN levels were also negatively related to VAS and WOMAC scores and positively associated with HSSs.Conclusion: Decreased serum APN levels may reflect disease severity of nontraumatic ONFH. Keywords: adiponectin, radiological severity, symptomatic severity, nontraumatic osteonecrosis of the femoral headhttps://www.dovepress.com/attenuated-serum-adiponectin-levels-are-associated-with-disease-severi-peer-reviewed-article-JPRadiponectinradiological severitysymptomatic severitynon-traumatic osteonecrosis of the femoral head |
| spellingShingle | Yue YB Liu X Wei BF Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral head Journal of Pain Research adiponectin radiological severity symptomatic severity non-traumatic osteonecrosis of the femoral head |
| title | Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral head |
| title_full | Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral head |
| title_fullStr | Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral head |
| title_full_unstemmed | Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral head |
| title_short | Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral head |
| title_sort | attenuated serum adiponectin levels are associated with disease severity in patients with non traumatic osteonecrosis of the femoral head |
| topic | adiponectin radiological severity symptomatic severity non-traumatic osteonecrosis of the femoral head |
| url | https://www.dovepress.com/attenuated-serum-adiponectin-levels-are-associated-with-disease-severi-peer-reviewed-article-JPR |
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