TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc

TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc

Abstract Background The ion channel transient receptor potential vanilloid 4 (TRPV4) critically transduces mechanical forces in the IVD, and its inhibition can prevent IVD degeneration due to static overloading. However, it remains unknown whether different modes of loading signals through TRPV4 to...

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Bibliographic Details
Main Authors: Garrett W. D. Easson, Alireza Savadipour, Christian Gonzalez, Farshid Guilak, Simon Y. Tang
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:JOR Spine
Subjects:
degeneration
dynamic compression
inflammatory cytokine networks
intervertebral disc
static compression
TRPV4
Online Access:https://doi.org/10.1002/jsp2.1282

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