Genomic basis of evolutionary change: Evolving immunity
Complex traits are manifestations of intricate gene interaction networks. Evolution of complex traits revolves around the genetic variation in such networks. Genomics has increased our ability to investigate the complex gene interaction networks, and characterize the extent of genetic variation in t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-06-01
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| Series: | Frontiers in Genetics |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00222/full |
| _version_ | 1818084531407683584 |
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| author | Bregje eWertheim |
| author_facet | Bregje eWertheim |
| author_sort | Bregje eWertheim |
| collection | DOAJ |
| description | Complex traits are manifestations of intricate gene interaction networks. Evolution of complex traits revolves around the genetic variation in such networks. Genomics has increased our ability to investigate the complex gene interaction networks, and characterize the extent of genetic variation in these networks. Immunity is a complex trait, for which the ecological drivers and molecular networks are fairly well understood in Drosophila. By characterizing the natural variation in immunity, and mapping how the genome changes during the evolution of immunity in Drosophila, we can integrate our knowledge on the complex genetic architecture of traits and the molecular basis of evolutionary processes. |
| first_indexed | 2024-12-10T19:55:22Z |
| format | Article |
| id | doaj.art-a07bd11300044d98b3f7f48039dd4410 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T19:55:22Z |
| publishDate | 2015-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-a07bd11300044d98b3f7f48039dd44102022-12-22T01:35:41ZengFrontiers Media S.A.Frontiers in Genetics1664-80212015-06-01610.3389/fgene.2015.00222148775Genomic basis of evolutionary change: Evolving immunityBregje eWertheim0University of GroningenComplex traits are manifestations of intricate gene interaction networks. Evolution of complex traits revolves around the genetic variation in such networks. Genomics has increased our ability to investigate the complex gene interaction networks, and characterize the extent of genetic variation in these networks. Immunity is a complex trait, for which the ecological drivers and molecular networks are fairly well understood in Drosophila. By characterizing the natural variation in immunity, and mapping how the genome changes during the evolution of immunity in Drosophila, we can integrate our knowledge on the complex genetic architecture of traits and the molecular basis of evolutionary processes.http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00222/fulladaptationevolutioninnate immunitycomplex traitsMolecular mechanismsGene interaction networks |
| spellingShingle | Bregje eWertheim Genomic basis of evolutionary change: Evolving immunity Frontiers in Genetics adaptation evolution innate immunity complex traits Molecular mechanisms Gene interaction networks |
| title | Genomic basis of evolutionary change: Evolving immunity |
| title_full | Genomic basis of evolutionary change: Evolving immunity |
| title_fullStr | Genomic basis of evolutionary change: Evolving immunity |
| title_full_unstemmed | Genomic basis of evolutionary change: Evolving immunity |
| title_short | Genomic basis of evolutionary change: Evolving immunity |
| title_sort | genomic basis of evolutionary change evolving immunity |
| topic | adaptation evolution innate immunity complex traits Molecular mechanisms Gene interaction networks |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00222/full |
| work_keys_str_mv | AT bregjeewertheim genomicbasisofevolutionarychangeevolvingimmunity |