G protein βγ regulation of KCNQ-encoded voltage-dependent K channels
The KCNQ family is comprised of five genes and the expression products form voltage-gated potassium channels (Kv7.1–7.5) that have a major impact upon cellular physiology in many cell types. Each functional Kv7 channel forms as a tetramer that often associates with proteins encoded by the KCNE gene...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1382904/full |
| _version_ | 1797217051702460416 |
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| author | Jennifer B. Stott Iain A. Greenwood |
| author_facet | Jennifer B. Stott Iain A. Greenwood |
| author_sort | Jennifer B. Stott |
| collection | DOAJ |
| description | The KCNQ family is comprised of five genes and the expression products form voltage-gated potassium channels (Kv7.1–7.5) that have a major impact upon cellular physiology in many cell types. Each functional Kv7 channel forms as a tetramer that often associates with proteins encoded by the KCNE gene family (KCNE1-5) and is critically reliant upon binding of phosphatidylinositol bisphosphate (PIP2) and calmodulin. Other modulators like A-kinase anchoring proteins, ubiquitin ligases and Ca-calmodulin kinase II alter Kv7 channel function and trafficking in an isoform specific manner. It has now been identified that for Kv7.4, G protein βγ subunits (Gβγ) can be added to the list of key regulators and is paramount for channel activity. This article provides an overview of this nascent field of research, highlighting themes and directions for future study. |
| first_indexed | 2024-04-24T11:55:43Z |
| format | Article |
| id | doaj.art-a07e7dbec107485b9c438c034852acb0 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-24T11:55:43Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-a07e7dbec107485b9c438c034852acb02024-04-09T04:43:49ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-04-011510.3389/fphys.2024.13829041382904G protein βγ regulation of KCNQ-encoded voltage-dependent K channelsJennifer B. StottIain A. GreenwoodThe KCNQ family is comprised of five genes and the expression products form voltage-gated potassium channels (Kv7.1–7.5) that have a major impact upon cellular physiology in many cell types. Each functional Kv7 channel forms as a tetramer that often associates with proteins encoded by the KCNE gene family (KCNE1-5) and is critically reliant upon binding of phosphatidylinositol bisphosphate (PIP2) and calmodulin. Other modulators like A-kinase anchoring proteins, ubiquitin ligases and Ca-calmodulin kinase II alter Kv7 channel function and trafficking in an isoform specific manner. It has now been identified that for Kv7.4, G protein βγ subunits (Gβγ) can be added to the list of key regulators and is paramount for channel activity. This article provides an overview of this nascent field of research, highlighting themes and directions for future study.https://www.frontiersin.org/articles/10.3389/fphys.2024.1382904/fullKv7KCNQGβγM channelvasorelaxation |
| spellingShingle | Jennifer B. Stott Iain A. Greenwood G protein βγ regulation of KCNQ-encoded voltage-dependent K channels Frontiers in Physiology Kv7 KCNQ Gβγ M channel vasorelaxation |
| title | G protein βγ regulation of KCNQ-encoded voltage-dependent K channels |
| title_full | G protein βγ regulation of KCNQ-encoded voltage-dependent K channels |
| title_fullStr | G protein βγ regulation of KCNQ-encoded voltage-dependent K channels |
| title_full_unstemmed | G protein βγ regulation of KCNQ-encoded voltage-dependent K channels |
| title_short | G protein βγ regulation of KCNQ-encoded voltage-dependent K channels |
| title_sort | g protein βγ regulation of kcnq encoded voltage dependent k channels |
| topic | Kv7 KCNQ Gβγ M channel vasorelaxation |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1382904/full |
| work_keys_str_mv | AT jenniferbstott gproteinbgregulationofkcnqencodedvoltagedependentkchannels AT iainagreenwood gproteinbgregulationofkcnqencodedvoltagedependentkchannels |