SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension

SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension

Animals respond to mitochondrial stress with the induction of mitochondrial unfolded protein response (UPRmt). A cascade of events occur upon UPRmt activation, ultimately triggering a transcriptional response governed by two transcription factors: DVE-1 and ATFS-1. Here we identify SUMO-specific pep...

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Bibliographic Details
Main Authors: Kaiyu Gao, Yi Li, Shumei Hu, Ying Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
mitochondria
stress response
sumoylation
Online Access:https://elifesciences.org/articles/41792

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