The prevalence and distribution of aminoglycoside resistance genes
Choosing the appropriate antibiotics to treat bacterial infections has grown more challenging as a result of the emergence of antibiotic-resistant bacteria. Aminoglycosides, as broad-spectrum antibiotics, are increasingly being used clinically; however, for most effective employment of aminoglycosid...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Biosafety and Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590053623000010 |
| _version_ | 1797894953194487808 |
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| author | Yuan Zhang Ning Zhang Mengyu Wang Ming Luo Yao Peng Zhenpeng Li Jialiang Xu Meiling Ou Biao Kan Xu Li Xin Lu |
| author_facet | Yuan Zhang Ning Zhang Mengyu Wang Ming Luo Yao Peng Zhenpeng Li Jialiang Xu Meiling Ou Biao Kan Xu Li Xin Lu |
| author_sort | Yuan Zhang |
| collection | DOAJ |
| description | Choosing the appropriate antibiotics to treat bacterial infections has grown more challenging as a result of the emergence of antibiotic-resistant bacteria. Aminoglycosides, as broad-spectrum antibiotics, are increasingly being used clinically; however, for most effective employment of aminoglycosides, a comprehensive understanding of aminoglycoside resistance genes’ prevalence and dissemination is required. Therefore, to better understand the global resistance status of aminoglycoside antibiotics and the prevalence of antibiotic-resistance genes (ARGs) in various bacterial species, this systematic review gathered relevant data from multiple studies. Two primary resistance mechanisms—aminoglycoside enzymatic modification and 16S rRNA methylation—were assessed, and the prevalence of the corresponding ARGs was described. The coexistence of aminoglycoside ARGs with other ARGs was also demonstrated, as was the relationship between aminoglycoside ARGs and resistant phenotypes. The lack of effective therapeutic agents to combat resistant pathogens presents a real threat to public health. The combination of aminoglycosides with other antibiotics may provide a novel treatment strategy. |
| first_indexed | 2024-04-10T07:17:40Z |
| format | Article |
| id | doaj.art-a081f9ffd1a44c95bf32f116cbcfede5 |
| institution | Directory Open Access Journal |
| issn | 2590-0536 |
| language | English |
| last_indexed | 2024-04-10T07:17:40Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosafety and Health |
| spelling | doaj.art-a081f9ffd1a44c95bf32f116cbcfede52023-02-25T04:10:00ZengElsevierBiosafety and Health2590-05362023-02-01511420The prevalence and distribution of aminoglycoside resistance genesYuan Zhang0Ning Zhang1Mengyu Wang2Ming Luo3Yao Peng4Zhenpeng Li5Jialiang Xu6Meiling Ou7Biao Kan8Xu Li9Xin Lu10National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Beijing Technology and Business University, Beijing 102488, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; School of Public Health, Shandong University, Jinan 250012, ChinaYulin Center for Disease Control and Prevention, Guangxi 537000, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaBeijing Technology and Business University, Beijing 102488, ChinaBeijing Technology and Business University, Beijing 102488, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; School of Public Health, Shandong University, Jinan 250012, ChinaBeijing Technology and Business University, Beijing 102488, China; Corresponding authors: Beijing Technology and Business University, Beijing 102488, China (X. Li); National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China (X. Lu).National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Corresponding authors: Beijing Technology and Business University, Beijing 102488, China (X. Li); National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China (X. Lu).Choosing the appropriate antibiotics to treat bacterial infections has grown more challenging as a result of the emergence of antibiotic-resistant bacteria. Aminoglycosides, as broad-spectrum antibiotics, are increasingly being used clinically; however, for most effective employment of aminoglycosides, a comprehensive understanding of aminoglycoside resistance genes’ prevalence and dissemination is required. Therefore, to better understand the global resistance status of aminoglycoside antibiotics and the prevalence of antibiotic-resistance genes (ARGs) in various bacterial species, this systematic review gathered relevant data from multiple studies. Two primary resistance mechanisms—aminoglycoside enzymatic modification and 16S rRNA methylation—were assessed, and the prevalence of the corresponding ARGs was described. The coexistence of aminoglycoside ARGs with other ARGs was also demonstrated, as was the relationship between aminoglycoside ARGs and resistant phenotypes. The lack of effective therapeutic agents to combat resistant pathogens presents a real threat to public health. The combination of aminoglycosides with other antibiotics may provide a novel treatment strategy.http://www.sciencedirect.com/science/article/pii/S2590053623000010AminoglycosideAminoglycoside resistanceAminoglycoside resistance geneAminoglycoside modifying enzyme16S rRNA methylation enzyme |
| spellingShingle | Yuan Zhang Ning Zhang Mengyu Wang Ming Luo Yao Peng Zhenpeng Li Jialiang Xu Meiling Ou Biao Kan Xu Li Xin Lu The prevalence and distribution of aminoglycoside resistance genes Biosafety and Health Aminoglycoside Aminoglycoside resistance Aminoglycoside resistance gene Aminoglycoside modifying enzyme 16S rRNA methylation enzyme |
| title | The prevalence and distribution of aminoglycoside resistance genes |
| title_full | The prevalence and distribution of aminoglycoside resistance genes |
| title_fullStr | The prevalence and distribution of aminoglycoside resistance genes |
| title_full_unstemmed | The prevalence and distribution of aminoglycoside resistance genes |
| title_short | The prevalence and distribution of aminoglycoside resistance genes |
| title_sort | prevalence and distribution of aminoglycoside resistance genes |
| topic | Aminoglycoside Aminoglycoside resistance Aminoglycoside resistance gene Aminoglycoside modifying enzyme 16S rRNA methylation enzyme |
| url | http://www.sciencedirect.com/science/article/pii/S2590053623000010 |
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