Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

The canonical target of the glucagon-like peptide-1 receptor (GLP-1R), Protein Kinase A (PKA), has been shown to stimulate mechanistic Target of Rapamycin Complex 1 (mTORC1) by phosphorylating the mTOR-regulating protein Raptor at Ser791 following β-adrenergic stimulation. The objective of these stu...

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Bibliographic Details
Main Authors: Thao DV Le, Dianxin Liu, Gai-Linn K Besing, Ritika Raghavan, Blair J Ellis, Ryan P Ceddia, Sheila Collins, Julio E Ayala
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-11-01
Series:eLife
Subjects:
glucagon-like peptide-1
mechanistic target of rapamycin
raptor
protein kinase A
body weight
Online Access:https://elifesciences.org/articles/80944

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