Impact of Ovarian Endometrioma and Surgery on Reproductive Outcomes: A Single-Center Spanish Cohort Study
Anti-Müllerian hormone (AMH) and antral follicular count (AFC) decrease in women with ovarian endometrioma (OMA) and in vitro fertilization (IVF). In addition, these parameters drop even further when women with OMA undergo surgery. In this study, the primary aim was to compare the reproductive varia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/844 |
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| author | Alicia Hernández Angela Sanz Emanuela Spagnolo Ana Lopez Paloma Martínez Jorge Silvia Iniesta Elena Rodríguez Sara Fernández Prada David Ramiro-Cortijo |
| author_facet | Alicia Hernández Angela Sanz Emanuela Spagnolo Ana Lopez Paloma Martínez Jorge Silvia Iniesta Elena Rodríguez Sara Fernández Prada David Ramiro-Cortijo |
| author_sort | Alicia Hernández |
| collection | DOAJ |
| description | Anti-Müllerian hormone (AMH) and antral follicular count (AFC) decrease in women with ovarian endometrioma (OMA) and in vitro fertilization (IVF). In addition, these parameters drop even further when women with OMA undergo surgery. In this study, the primary aim was to compare the reproductive variables in IVF-treated women with and without endometriosis. The secondary aim was to explore if the reproductive variables were modified by endometrioma surgery. In this retrospective study, 244 women undergoing IVF were enrolled at the Hospital Universitario La Paz (Madrid, Spain). Women were categorized as OMA not surgically treated (OMA; <i>n</i> = 124), OMA with surgery (OMA + S; <i>n</i> = 55), and women with infertility issues not related to OMA (control; <i>n</i> = 65). Demographic and clinical variables, including age, body mass index (BMI), and reproductive (AMH, AFC, number of extracted oocytes, and transferred embryos) and obstetrical data (biochemical pregnancy and fetal heart rate at 6 weeks) were collected. Adjusted logistic regression models were built to evaluate reproductive and pregnancy outcomes. The models showed that women with OMA (with and without surgery) had significantly decreased levels of AMH and AFC and numbers of cycles and C + D embryos. Women with OMA + S had similar rates of pregnancy to women in the control group. However, women with OMA had lower biochemical pregnancy than controls (aOR = 0.08 [0.01; 0.50]; <i>p</i>-value = 0.025). OMA surgery seems to improve pregnancy outcomes, at least until 6 weeks of gestation. However, it is important to counsel the patients about surgery expectations due to the fact that endometrioma itself reduces the quality of oocytes. |
| first_indexed | 2024-03-11T06:53:46Z |
| format | Article |
| id | doaj.art-a0848da8d803418ab273bfed2df8853c |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:46Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a0848da8d803418ab273bfed2df8853c2023-11-17T09:46:27ZengMDPI AGBiomedicines2227-90592023-03-0111384410.3390/biomedicines11030844Impact of Ovarian Endometrioma and Surgery on Reproductive Outcomes: A Single-Center Spanish Cohort StudyAlicia Hernández0Angela Sanz1Emanuela Spagnolo2Ana Lopez3Paloma Martínez Jorge4Silvia Iniesta5Elena Rodríguez6Sara Fernández Prada7David Ramiro-Cortijo8Department of Obstetrics and Gynecology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Obstetrics and Gynecology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Obstetrics and Gynecology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Obstetrics and Gynecology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Obstetrics and Gynecology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Obstetrics and Gynecology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Obstetrics and Gynecology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Obstetrics and Gynecology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, SpainAnti-Müllerian hormone (AMH) and antral follicular count (AFC) decrease in women with ovarian endometrioma (OMA) and in vitro fertilization (IVF). In addition, these parameters drop even further when women with OMA undergo surgery. In this study, the primary aim was to compare the reproductive variables in IVF-treated women with and without endometriosis. The secondary aim was to explore if the reproductive variables were modified by endometrioma surgery. In this retrospective study, 244 women undergoing IVF were enrolled at the Hospital Universitario La Paz (Madrid, Spain). Women were categorized as OMA not surgically treated (OMA; <i>n</i> = 124), OMA with surgery (OMA + S; <i>n</i> = 55), and women with infertility issues not related to OMA (control; <i>n</i> = 65). Demographic and clinical variables, including age, body mass index (BMI), and reproductive (AMH, AFC, number of extracted oocytes, and transferred embryos) and obstetrical data (biochemical pregnancy and fetal heart rate at 6 weeks) were collected. Adjusted logistic regression models were built to evaluate reproductive and pregnancy outcomes. The models showed that women with OMA (with and without surgery) had significantly decreased levels of AMH and AFC and numbers of cycles and C + D embryos. Women with OMA + S had similar rates of pregnancy to women in the control group. However, women with OMA had lower biochemical pregnancy than controls (aOR = 0.08 [0.01; 0.50]; <i>p</i>-value = 0.025). OMA surgery seems to improve pregnancy outcomes, at least until 6 weeks of gestation. However, it is important to counsel the patients about surgery expectations due to the fact that endometrioma itself reduces the quality of oocytes.https://www.mdpi.com/2227-9059/11/3/844endometriosisin vitro fertilizationsurgically treatmentovarian endometriomaovarian reservereproductive outcomes |
| spellingShingle | Alicia Hernández Angela Sanz Emanuela Spagnolo Ana Lopez Paloma Martínez Jorge Silvia Iniesta Elena Rodríguez Sara Fernández Prada David Ramiro-Cortijo Impact of Ovarian Endometrioma and Surgery on Reproductive Outcomes: A Single-Center Spanish Cohort Study Biomedicines endometriosis in vitro fertilization surgically treatment ovarian endometrioma ovarian reserve reproductive outcomes |
| title | Impact of Ovarian Endometrioma and Surgery on Reproductive Outcomes: A Single-Center Spanish Cohort Study |
| title_full | Impact of Ovarian Endometrioma and Surgery on Reproductive Outcomes: A Single-Center Spanish Cohort Study |
| title_fullStr | Impact of Ovarian Endometrioma and Surgery on Reproductive Outcomes: A Single-Center Spanish Cohort Study |
| title_full_unstemmed | Impact of Ovarian Endometrioma and Surgery on Reproductive Outcomes: A Single-Center Spanish Cohort Study |
| title_short | Impact of Ovarian Endometrioma and Surgery on Reproductive Outcomes: A Single-Center Spanish Cohort Study |
| title_sort | impact of ovarian endometrioma and surgery on reproductive outcomes a single center spanish cohort study |
| topic | endometriosis in vitro fertilization surgically treatment ovarian endometrioma ovarian reserve reproductive outcomes |
| url | https://www.mdpi.com/2227-9059/11/3/844 |
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