Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage
The development of the gastric lesion is complex and the result of the imbalance between aggressive and protective factors, involving the generation of free radicals and disturbance in nitric oxide (NO) production. Sulphated polysaccharides (SP), from marine algae, are widely used in biotechnologica...
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MDPI AG
2018-01-01
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| Series: | Pharmaceuticals |
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| Online Access: | http://www.mdpi.com/1424-8247/11/1/6 |
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| author | José Gerardo Carneiro Ticiana de Brito Lima Holanda Ana Luíza Gomes Quinderé Annyta Fernandes Frota Vitória Virgínia Magalhães Soares Rayane Siqueira de Sousa Manuela Araújo Carneiro Dainesy Santos Martins Antoniella Souza Gomes Duarte Norma Maria Barros Benevides |
| author_facet | José Gerardo Carneiro Ticiana de Brito Lima Holanda Ana Luíza Gomes Quinderé Annyta Fernandes Frota Vitória Virgínia Magalhães Soares Rayane Siqueira de Sousa Manuela Araújo Carneiro Dainesy Santos Martins Antoniella Souza Gomes Duarte Norma Maria Barros Benevides |
| author_sort | José Gerardo Carneiro |
| collection | DOAJ |
| description | The development of the gastric lesion is complex and the result of the imbalance between aggressive and protective factors, involving the generation of free radicals and disturbance in nitric oxide (NO) production. Sulphated polysaccharides (SP), from marine algae, are widely used in biotechnological and pharmaceutical areas. In this study, we evaluated the effects of SP from the green marine alga Caulerpa mexicana (Cm-SP) in ethanol-induced gastric damage models in mice. Cm-SP (2, 20, or 200 mg/kg), administered p.o., significantly reduced gastric damage, and these effects were inhibited through pretreatment with indomethacin. Cm-SP (200 mg/kg) prevented the ethanol-induced decline in glutathione and restored its normal level. Moreover, it was able to normalize the elevated thiobarbituric acid reactive substance levels. However, Cm-SP did not show any significant effects on NO2/NO3 level, when compared to the ethanol group. The pretreatment with L- NAME induced gastric mucosal damage and did not inhibit the gastroprotective effect of Cm-SP (200 mg/kg). In conclusion, the gastroprotective effects of Cm-SP in mice involve prostaglandins and reduction in the oxidative stress and are independent of NO. |
| first_indexed | 2024-12-19T14:43:11Z |
| format | Article |
| id | doaj.art-a085b439ed95480fb572ae3fba686693 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-19T14:43:11Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-a085b439ed95480fb572ae3fba6866932022-12-21T20:17:01ZengMDPI AGPharmaceuticals1424-82472018-01-01111610.3390/ph11010006ph11010006Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric DamageJosé Gerardo Carneiro0Ticiana de Brito Lima Holanda1Ana Luíza Gomes Quinderé2Annyta Fernandes Frota3Vitória Virgínia Magalhães Soares4Rayane Siqueira de Sousa5Manuela Araújo Carneiro6Dainesy Santos Martins7Antoniella Souza Gomes Duarte8Norma Maria Barros Benevides9Department of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, BrazilDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, BrazilDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, BrazilDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, BrazilDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, BrazilDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, BrazilDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, BrazilDepartment of Morphoology, Faculty of Medicine, Federal University of Ceará, s/n Delmiro de Farias Street, Porangabuçu Campus, 60416-030 Fortaleza, BrazilDepartment of Morphoology, Faculty of Medicine, Federal University of Ceará, s/n Delmiro de Farias Street, Porangabuçu Campus, 60416-030 Fortaleza, BrazilDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, BrazilThe development of the gastric lesion is complex and the result of the imbalance between aggressive and protective factors, involving the generation of free radicals and disturbance in nitric oxide (NO) production. Sulphated polysaccharides (SP), from marine algae, are widely used in biotechnological and pharmaceutical areas. In this study, we evaluated the effects of SP from the green marine alga Caulerpa mexicana (Cm-SP) in ethanol-induced gastric damage models in mice. Cm-SP (2, 20, or 200 mg/kg), administered p.o., significantly reduced gastric damage, and these effects were inhibited through pretreatment with indomethacin. Cm-SP (200 mg/kg) prevented the ethanol-induced decline in glutathione and restored its normal level. Moreover, it was able to normalize the elevated thiobarbituric acid reactive substance levels. However, Cm-SP did not show any significant effects on NO2/NO3 level, when compared to the ethanol group. The pretreatment with L- NAME induced gastric mucosal damage and did not inhibit the gastroprotective effect of Cm-SP (200 mg/kg). In conclusion, the gastroprotective effects of Cm-SP in mice involve prostaglandins and reduction in the oxidative stress and are independent of NO.http://www.mdpi.com/1424-8247/11/1/6marine algagastric ulcergastroprotectioncytoprotection |
| spellingShingle | José Gerardo Carneiro Ticiana de Brito Lima Holanda Ana Luíza Gomes Quinderé Annyta Fernandes Frota Vitória Virgínia Magalhães Soares Rayane Siqueira de Sousa Manuela Araújo Carneiro Dainesy Santos Martins Antoniella Souza Gomes Duarte Norma Maria Barros Benevides Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage Pharmaceuticals marine alga gastric ulcer gastroprotection cytoprotection |
| title | Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage |
| title_full | Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage |
| title_fullStr | Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage |
| title_full_unstemmed | Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage |
| title_short | Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage |
| title_sort | gastroprotective effects of sulphated polysaccharides from the alga caulerpa mexicana reducing ethanol induced gastric damage |
| topic | marine alga gastric ulcer gastroprotection cytoprotection |
| url | http://www.mdpi.com/1424-8247/11/1/6 |
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