A novel ex vivo perfusion-based mandibular pig model for dental product testing and training
Abstract Background A translational ex vivo perfusion-based mandibular pig model was developed as an alternative to animal experiments, for initial assessment of biomaterials in dental and maxillofacial surgery and training. This study aimed to assess the face and content validity of the novel perfu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-023-02794-6 |
| _version_ | 1827982505995665408 |
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| author | Machteld van Erk Roger M. L. M. Lomme Edwin A. Roozen Bart A. J. A. van Oirschot Harry van Goor |
| author_facet | Machteld van Erk Roger M. L. M. Lomme Edwin A. Roozen Bart A. J. A. van Oirschot Harry van Goor |
| author_sort | Machteld van Erk |
| collection | DOAJ |
| description | Abstract Background A translational ex vivo perfusion-based mandibular pig model was developed as an alternative to animal experiments, for initial assessment of biomaterials in dental and maxillofacial surgery and training. This study aimed to assess the face and content validity of the novel perfusion-based model. Methods Cadaveric porcine heads were connected to an organ assist perfusion device for blood circulation and tissue oxygenation. Dental professionals and dental trainees performed a surgical procedure on the mandibula resembling a submandibular extraoral incision to create bone defects. The bone defects were filled and covered with a commercial barrier membrane. All participants completed a questionnaire using a 5-point Likert scale to assess the face and content validity of the model. Validation data between the two groups of participants were compared with Mann–Whitney U test. Results Ten dental professionals and seven trainees evaluated the model for face and content validity. Participants reported model realism, with a mean face validity score of 3.9 ± 1.0 and a content validity of 4.1 ± 0.8. No significant differences were found for overall face and content validity between experts and trainees. Conclusion We established face and content validity in a novel perfusion-based mandibular surgery model. This model can be used as an alternative for animal studies evaluating new biomaterials and related dental and maxillofacial surgical procedural training. |
| first_indexed | 2024-04-09T22:34:06Z |
| format | Article |
| id | doaj.art-a086d2e800a14d1b83254316b8199206 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-09T22:34:06Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-a086d2e800a14d1b83254316b81992062023-03-22T12:34:34ZengBMCBMC Oral Health1472-68312023-02-012311910.1186/s12903-023-02794-6A novel ex vivo perfusion-based mandibular pig model for dental product testing and trainingMachteld van Erk0Roger M. L. M. Lomme1Edwin A. Roozen2Bart A. J. A. van Oirschot3Harry van Goor4Department of Surgery (Route 618), Radboud University Medical CentreDepartment of Surgery (Route 618), Radboud University Medical CentreDepartment of Surgery (Route 618), Radboud University Medical CentreDepartment of Dentistry – Regenerative Biomaterials, Radboud University Medical CentreDepartment of Surgery (Route 618), Radboud University Medical CentreAbstract Background A translational ex vivo perfusion-based mandibular pig model was developed as an alternative to animal experiments, for initial assessment of biomaterials in dental and maxillofacial surgery and training. This study aimed to assess the face and content validity of the novel perfusion-based model. Methods Cadaveric porcine heads were connected to an organ assist perfusion device for blood circulation and tissue oxygenation. Dental professionals and dental trainees performed a surgical procedure on the mandibula resembling a submandibular extraoral incision to create bone defects. The bone defects were filled and covered with a commercial barrier membrane. All participants completed a questionnaire using a 5-point Likert scale to assess the face and content validity of the model. Validation data between the two groups of participants were compared with Mann–Whitney U test. Results Ten dental professionals and seven trainees evaluated the model for face and content validity. Participants reported model realism, with a mean face validity score of 3.9 ± 1.0 and a content validity of 4.1 ± 0.8. No significant differences were found for overall face and content validity between experts and trainees. Conclusion We established face and content validity in a novel perfusion-based mandibular surgery model. This model can be used as an alternative for animal studies evaluating new biomaterials and related dental and maxillofacial surgical procedural training.https://doi.org/10.1186/s12903-023-02794-6BiomaterialsGuided tissue regenerationSurgical techniquesWound healingDental modelPerfusion |
| spellingShingle | Machteld van Erk Roger M. L. M. Lomme Edwin A. Roozen Bart A. J. A. van Oirschot Harry van Goor A novel ex vivo perfusion-based mandibular pig model for dental product testing and training BMC Oral Health Biomaterials Guided tissue regeneration Surgical techniques Wound healing Dental model Perfusion |
| title | A novel ex vivo perfusion-based mandibular pig model for dental product testing and training |
| title_full | A novel ex vivo perfusion-based mandibular pig model for dental product testing and training |
| title_fullStr | A novel ex vivo perfusion-based mandibular pig model for dental product testing and training |
| title_full_unstemmed | A novel ex vivo perfusion-based mandibular pig model for dental product testing and training |
| title_short | A novel ex vivo perfusion-based mandibular pig model for dental product testing and training |
| title_sort | novel ex vivo perfusion based mandibular pig model for dental product testing and training |
| topic | Biomaterials Guided tissue regeneration Surgical techniques Wound healing Dental model Perfusion |
| url | https://doi.org/10.1186/s12903-023-02794-6 |
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