Reprogramming stem cells in regenerative medicine
Abstract Induced pluripotent stem cells (iPSCs) that are generated from adult somatic cells are induced to express genes that make them pluripotent through reprogramming techniques. With their unlimited proliferative capacity and multifaceted differentiation potential and circumventing the ethical p...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2022-12-01
|
| Series: | Smart Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/SMMD.20220005 |
| _version_ | 1797796745299623936 |
|---|---|
| author | Jiayi Mao Qimanguli Saiding Shutong Qian Zhimo Liu Binfan Zhao Qiuyu Zhao Bolun Lu Xiyuan Mao Liucheng Zhang Yuguang Zhang Xiaoming Sun Wenguo Cui |
| author_facet | Jiayi Mao Qimanguli Saiding Shutong Qian Zhimo Liu Binfan Zhao Qiuyu Zhao Bolun Lu Xiyuan Mao Liucheng Zhang Yuguang Zhang Xiaoming Sun Wenguo Cui |
| author_sort | Jiayi Mao |
| collection | DOAJ |
| description | Abstract Induced pluripotent stem cells (iPSCs) that are generated from adult somatic cells are induced to express genes that make them pluripotent through reprogramming techniques. With their unlimited proliferative capacity and multifaceted differentiation potential and circumventing the ethical problems encountered in the application of embryonic stem cells (ESC), iPSCs have a broad application in the fields of cell therapy, drug screening, and disease models and may open up new possibilities for regenerative medicine to treat diseases in the future. In this review, we begin with different reprogramming cell technologies to obtain iPSCs, including biotechnological, chemical, and physical modulation techniques, and present their respective strengths, and limitations, as well as the recent progress of research. Secondly, we review recent research advances in iPSC reprogramming‐based regenerative therapies. iPSCs are now widely used to study various clinical diseases of hair follicle defects, myocardial infarction, neurological disorders, liver diseases, and spinal cord injuries. This review focuses on the translational clinical research around iPSCs as well as their potential for growth in the medical field. Finally, we summarize the overall review and look at the potential future of iPSCs in the field of cell therapy as well as tissue regeneration engineering and possible problems. We believe that the advancing iPSC research will help drive long‐awaited breakthroughs in cellular therapy. |
| first_indexed | 2024-03-13T03:37:41Z |
| format | Article |
| id | doaj.art-a087082411a94d198e8172870ab3571e |
| institution | Directory Open Access Journal |
| issn | 2751-1871 |
| language | English |
| last_indexed | 2024-03-13T03:37:41Z |
| publishDate | 2022-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj.art-a087082411a94d198e8172870ab3571e2023-06-23T15:10:31ZengWiley-VCHSmart Medicine2751-18712022-12-0111n/an/a10.1002/SMMD.20220005Reprogramming stem cells in regenerative medicineJiayi Mao0Qimanguli Saiding1Shutong Qian2Zhimo Liu3Binfan Zhao4Qiuyu Zhao5Bolun Lu6Xiyuan Mao7Liucheng Zhang8Yuguang Zhang9Xiaoming Sun10Wenguo Cui11Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract Induced pluripotent stem cells (iPSCs) that are generated from adult somatic cells are induced to express genes that make them pluripotent through reprogramming techniques. With their unlimited proliferative capacity and multifaceted differentiation potential and circumventing the ethical problems encountered in the application of embryonic stem cells (ESC), iPSCs have a broad application in the fields of cell therapy, drug screening, and disease models and may open up new possibilities for regenerative medicine to treat diseases in the future. In this review, we begin with different reprogramming cell technologies to obtain iPSCs, including biotechnological, chemical, and physical modulation techniques, and present their respective strengths, and limitations, as well as the recent progress of research. Secondly, we review recent research advances in iPSC reprogramming‐based regenerative therapies. iPSCs are now widely used to study various clinical diseases of hair follicle defects, myocardial infarction, neurological disorders, liver diseases, and spinal cord injuries. This review focuses on the translational clinical research around iPSCs as well as their potential for growth in the medical field. Finally, we summarize the overall review and look at the potential future of iPSCs in the field of cell therapy as well as tissue regeneration engineering and possible problems. We believe that the advancing iPSC research will help drive long‐awaited breakthroughs in cellular therapy.https://doi.org/10.1002/SMMD.20220005cell therapiescellular reprogramminghuman disease modelinduced pluripotent stem cellstissue regeneration |
| spellingShingle | Jiayi Mao Qimanguli Saiding Shutong Qian Zhimo Liu Binfan Zhao Qiuyu Zhao Bolun Lu Xiyuan Mao Liucheng Zhang Yuguang Zhang Xiaoming Sun Wenguo Cui Reprogramming stem cells in regenerative medicine Smart Medicine cell therapies cellular reprogramming human disease model induced pluripotent stem cells tissue regeneration |
| title | Reprogramming stem cells in regenerative medicine |
| title_full | Reprogramming stem cells in regenerative medicine |
| title_fullStr | Reprogramming stem cells in regenerative medicine |
| title_full_unstemmed | Reprogramming stem cells in regenerative medicine |
| title_short | Reprogramming stem cells in regenerative medicine |
| title_sort | reprogramming stem cells in regenerative medicine |
| topic | cell therapies cellular reprogramming human disease model induced pluripotent stem cells tissue regeneration |
| url | https://doi.org/10.1002/SMMD.20220005 |
| work_keys_str_mv | AT jiayimao reprogrammingstemcellsinregenerativemedicine AT qimangulisaiding reprogrammingstemcellsinregenerativemedicine AT shutongqian reprogrammingstemcellsinregenerativemedicine AT zhimoliu reprogrammingstemcellsinregenerativemedicine AT binfanzhao reprogrammingstemcellsinregenerativemedicine AT qiuyuzhao reprogrammingstemcellsinregenerativemedicine AT bolunlu reprogrammingstemcellsinregenerativemedicine AT xiyuanmao reprogrammingstemcellsinregenerativemedicine AT liuchengzhang reprogrammingstemcellsinregenerativemedicine AT yuguangzhang reprogrammingstemcellsinregenerativemedicine AT xiaomingsun reprogrammingstemcellsinregenerativemedicine AT wenguocui reprogrammingstemcellsinregenerativemedicine |