Indications and Outcomes of Amniotic Membrane Transplantation
Objectives: To investigate the indications and outcomes of amniotic membrane transplantation (AMT). Materials and Methods: A total of 87 eyes who underwent amnion membrane transplantation in our clinic between February 2010 and April 2013 were included in this study. Mean follow-up period was 7.49...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2014-03-01
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| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.oftalmoloji.org/article_2361/Indications-And-Outcomes-Of-Amniotic-Membrane-Transplantation |
| _version_ | 1797912138845519872 |
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| author | Alime Güneş Levent Tök Özlem Tök |
| author_facet | Alime Güneş Levent Tök Özlem Tök |
| author_sort | Alime Güneş |
| collection | DOAJ |
| description | Objectives: To investigate the indications and outcomes of amniotic membrane transplantation (AMT).
Materials and Methods: A total of 87 eyes who underwent amnion membrane transplantation in our clinic between February 2010
and April 2013 were included in this study. Mean follow-up period was 7.49±7.84 months (range 1-29 months). Amnion membrane
defrosted at room temperature and washed three times with saline covered all over the cornea independent of the position and size
of the lesion and was sutured to the peripheral cornea circumferentially by 10/0 monofilament suture. At the end of the operation,
therapeutic contact lens was placed. All cases were evaluated with respect to duration of surface epithelial healing, visual acuity, presence
of recurrence, and infection.
Results: Forty-six of the 87 patients (52.8%) were men and 41 (47.1%) were women. The mean age was 57.02±19.74 years (range
31-89 years) in men and 66.69±16.56 years (range 8-88 years) in women. The indications were: ulcers in 27 eyes, keratitis in 24 eyes,
topical anesthetic abuse in 10 eyes, bullous keratopathy in 7 eyes, conjunctival mass in 7 eyes, symblepharon in 3 eyes, chemical burns
in 3 eyes, pterygium in 2 eyes, endophthalmitis in 2 eyes, dellen in 1 eye, and conjunctival laceration in 1 eye. After AMT, 12 patients
required second AMT, and 2 cases required third AMT. 2 eyes were eviscerated, 1 eye was exenterated. At the final follow-up visit,
except for patients who underwent evisceration and exenteration, improved visual acuity was observed in 45 of the 84 eyes (53.5%).
The average of healing time was between 4 and 6 weeks. No infectious, inflammatory, immunologic, or toxic/allergic reactions related
to AMT was observed.
Conclusion: Amniotic membrane transplantation is a safe and effective technique in ocular surface diseases. (Turk J Ophthalmol
2014; 44: 123-6 |
| first_indexed | 2024-04-10T11:52:48Z |
| format | Article |
| id | doaj.art-a08722d4092d44959beead5cbaadfe69 |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T11:52:48Z |
| publishDate | 2014-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-a08722d4092d44959beead5cbaadfe692023-02-15T16:17:03ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612014-03-0144212312610.4274/tjo.99810Indications and Outcomes of Amniotic Membrane TransplantationAlime Güneş0Levent Tök1Özlem Tök2Süleyman Demirel Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Isparta, TürkiyeSüleyman Demirel Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Isparta, TürkiyeSüleyman Demirel Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Isparta, TürkiyeObjectives: To investigate the indications and outcomes of amniotic membrane transplantation (AMT). Materials and Methods: A total of 87 eyes who underwent amnion membrane transplantation in our clinic between February 2010 and April 2013 were included in this study. Mean follow-up period was 7.49±7.84 months (range 1-29 months). Amnion membrane defrosted at room temperature and washed three times with saline covered all over the cornea independent of the position and size of the lesion and was sutured to the peripheral cornea circumferentially by 10/0 monofilament suture. At the end of the operation, therapeutic contact lens was placed. All cases were evaluated with respect to duration of surface epithelial healing, visual acuity, presence of recurrence, and infection. Results: Forty-six of the 87 patients (52.8%) were men and 41 (47.1%) were women. The mean age was 57.02±19.74 years (range 31-89 years) in men and 66.69±16.56 years (range 8-88 years) in women. The indications were: ulcers in 27 eyes, keratitis in 24 eyes, topical anesthetic abuse in 10 eyes, bullous keratopathy in 7 eyes, conjunctival mass in 7 eyes, symblepharon in 3 eyes, chemical burns in 3 eyes, pterygium in 2 eyes, endophthalmitis in 2 eyes, dellen in 1 eye, and conjunctival laceration in 1 eye. After AMT, 12 patients required second AMT, and 2 cases required third AMT. 2 eyes were eviscerated, 1 eye was exenterated. At the final follow-up visit, except for patients who underwent evisceration and exenteration, improved visual acuity was observed in 45 of the 84 eyes (53.5%). The average of healing time was between 4 and 6 weeks. No infectious, inflammatory, immunologic, or toxic/allergic reactions related to AMT was observed. Conclusion: Amniotic membrane transplantation is a safe and effective technique in ocular surface diseases. (Turk J Ophthalmol 2014; 44: 123-6http://www.oftalmoloji.org/article_2361/Indications-And-Outcomes-Of-Amniotic-Membrane-TransplantationAmnion membrane transplantationcorneal ulcerkeratitis |
| spellingShingle | Alime Güneş Levent Tök Özlem Tök Indications and Outcomes of Amniotic Membrane Transplantation Türk Oftalmoloji Dergisi Amnion membrane transplantation corneal ulcer keratitis |
| title | Indications and Outcomes of Amniotic Membrane Transplantation |
| title_full | Indications and Outcomes of Amniotic Membrane Transplantation |
| title_fullStr | Indications and Outcomes of Amniotic Membrane Transplantation |
| title_full_unstemmed | Indications and Outcomes of Amniotic Membrane Transplantation |
| title_short | Indications and Outcomes of Amniotic Membrane Transplantation |
| title_sort | indications and outcomes of amniotic membrane transplantation |
| topic | Amnion membrane transplantation corneal ulcer keratitis |
| url | http://www.oftalmoloji.org/article_2361/Indications-And-Outcomes-Of-Amniotic-Membrane-Transplantation |
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