Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid [version 1; peer review: 4 approved]
Hypochlorous acid (HOCl; bleach) is a powerful weapon used by our immune system to eliminate invading bacteria. Yet the way HOCl actually kills bacteria and how they defend themselves from its oxidative action have only started to be uncovered. As this molecule induces both protein oxidation and agg...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2019-09-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-1678/v1 |
| _version_ | 1818146449095917568 |
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| author | Camille V. Goemans Jean-François Collet |
| author_facet | Camille V. Goemans Jean-François Collet |
| author_sort | Camille V. Goemans |
| collection | DOAJ |
| description | Hypochlorous acid (HOCl; bleach) is a powerful weapon used by our immune system to eliminate invading bacteria. Yet the way HOCl actually kills bacteria and how they defend themselves from its oxidative action have only started to be uncovered. As this molecule induces both protein oxidation and aggregation, bacteria need concerted efforts of chaperones and antioxidants to maintain proteostasis during stress. Recent advances in the field identified several stress-activated chaperones, like Hsp33, RidA, and CnoX, which display unique structural features and play a central role in protecting the bacterial proteome during HOCl stress. |
| first_indexed | 2024-12-11T12:19:31Z |
| format | Article |
| id | doaj.art-a08a8cf2c748416e95e718cf46aba48d |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T12:19:31Z |
| publishDate | 2019-09-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-a08a8cf2c748416e95e718cf46aba48d2022-12-22T01:07:34ZengF1000 Research LtdF1000Research2046-14022019-09-01810.12688/f1000research.19517.121397Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid [version 1; peer review: 4 approved]Camille V. Goemans0Jean-François Collet1European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germanyde Duve Institute, UCLouvain, Avenue Hippocrate 75, 1200 Brussels, BelgiumHypochlorous acid (HOCl; bleach) is a powerful weapon used by our immune system to eliminate invading bacteria. Yet the way HOCl actually kills bacteria and how they defend themselves from its oxidative action have only started to be uncovered. As this molecule induces both protein oxidation and aggregation, bacteria need concerted efforts of chaperones and antioxidants to maintain proteostasis during stress. Recent advances in the field identified several stress-activated chaperones, like Hsp33, RidA, and CnoX, which display unique structural features and play a central role in protecting the bacterial proteome during HOCl stress.https://f1000research.com/articles/8-1678/v1 |
| spellingShingle | Camille V. Goemans Jean-François Collet Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid [version 1; peer review: 4 approved] F1000Research |
| title | Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid [version 1; peer review: 4 approved] |
| title_full | Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid [version 1; peer review: 4 approved] |
| title_fullStr | Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid [version 1; peer review: 4 approved] |
| title_full_unstemmed | Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid [version 1; peer review: 4 approved] |
| title_short | Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid [version 1; peer review: 4 approved] |
| title_sort | stress induced chaperones a first line of defense against the powerful oxidant hypochlorous acid version 1 peer review 4 approved |
| url | https://f1000research.com/articles/8-1678/v1 |
| work_keys_str_mv | AT camillevgoemans stressinducedchaperonesafirstlineofdefenseagainstthepowerfuloxidanthypochlorousacidversion1peerreview4approved AT jeanfrancoiscollet stressinducedchaperonesafirstlineofdefenseagainstthepowerfuloxidanthypochlorousacidversion1peerreview4approved |