Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines

Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines

Cannabinoid receptor 2 (CB2) is predominantly distributed in immune tissues and cells and is a promising therapeutic target for modulating inflammation. In this study we designed and synthesised a series of 2,4,6-trisubstituted 1,3,5-triazines with piperazinylalkyl or 1,2-diethoxyethane (PEG2) chain...

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Bibliographic Details
Main Authors: Caitlin R. M. Oyagawa, Sara M. de la Harpe, Yurii Saroz, Michelle Glass, Andrea J. Vernall, Natasha Lillia Grimsey
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
cannabinoid receptor 2 (CB2)
G protein-coupled receptor
signalling bias
signalling
synthetic cannabinoid
drug design
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01202/full

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