Natural Killer Cells and Neuroblastoma: tumor recognition, escape mechanisms and possible novel immunotherapeutic approaches

Natural Killer Cells and Neuroblastoma: tumor recognition, escape mechanisms and possible novel immunotherapeutic approaches

Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and arises from developing sympathetic nervous system. Most primary tumors localize in the abdomen, the adrenal gland or lumbar sympathetic ganglia. Amplification in tumor cells of MYCN, the major oncogenic driver, patients...

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Bibliographic Details
Main Authors: Cristina eBottino, Alessandra eDondero, Francesca eBellora, Lorenzo eMoretta, Franco eLocatelli, Vito ePistoia, Alessandro eMoretta, Roberta eCastriconi
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Immunology
Subjects:
Exosomes
Neuroblastoma
Chemokine receptors
natural killer (NK) cells
TGF-beta
anti-tumor immunity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00056/full

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