| Summary: | <p class="orbitalabstract">Substantial conformational changes of human serum albumin, HSA, induced by Lanthanide chlorides (Ce<sup>3+,</sup> La<sup>3+,</sup> Er<sup>3+</sup>) in phosphate buffer, 10 mmol L<sup>-1</sup> at pH 7.4, was studied by Isothermal Titration Calorimetry, ITC. The strong negative cooperativity of Lanthanide chlorides interaction with HSA recovered from the extended solvation model, indicates that HSA denatures as a result of its interaction with toxic Lanthanide chlorides.</p><p class="orbitalabstract"> </p><p class="orbitalabstract">DOI: <a href="http://dx.doi.org/10.17807/orbital.v9i1.941">http://dx.doi.org/10.17807/orbital.v9i1.941</a></p><p> </p>
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