EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma
This study aimed to develop a model using Epstein–Barr virus (EBV)-associated hub genes in order to predict the prognosis of nasopharyngeal carcinoma (NPC). Differential expression analysis, univariate regression analysis, and machine learning were performed in three microarray datasets (GSE2371, GS...
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MDPI AG
2023-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/9/1915 |
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| author | Tengteng Ding Yuanbin Zhang Zhixuan Ren Ying Cong Jingyi Long Manli Peng Oluwasijibomi Damola Faleti Yinggui Yang Xin Li Xiaoming Lyu |
| author_facet | Tengteng Ding Yuanbin Zhang Zhixuan Ren Ying Cong Jingyi Long Manli Peng Oluwasijibomi Damola Faleti Yinggui Yang Xin Li Xiaoming Lyu |
| author_sort | Tengteng Ding |
| collection | DOAJ |
| description | This study aimed to develop a model using Epstein–Barr virus (EBV)-associated hub genes in order to predict the prognosis of nasopharyngeal carcinoma (NPC). Differential expression analysis, univariate regression analysis, and machine learning were performed in three microarray datasets (GSE2371, GSE12452, and GSE102349) collected from the GEO database. Three hundred and sixty-six EBV-DEGs were identified, 25 of which were found to be significantly associated with NPC prognosis. These 25 genes were used to classify NPC into two subtypes, and six genes (C16orf54, CD27, CD53, CRIP1, RARRES3, and TBC1D10C) were found to be hub genes in NPC related to immune infiltration and cell cycle regulation. It was shown that these genes could be used to predict the prognosis of NPC, with functions related to tumor proliferation and immune infiltration, making them potential therapeutic targets. The findings of this study could aid in the development of screening and prognostic methods for NPC based on EBV-related features. |
| first_indexed | 2024-03-10T21:51:43Z |
| format | Article |
| id | doaj.art-a08f7caf95814f04bf9182aa5efbf66d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T21:51:43Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a08f7caf95814f04bf9182aa5efbf66d2023-11-19T13:23:31ZengMDPI AGViruses1999-49152023-09-01159191510.3390/v15091915EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal CarcinomaTengteng Ding0Yuanbin Zhang1Zhixuan Ren2Ying Cong3Jingyi Long4Manli Peng5Oluwasijibomi Damola Faleti6Yinggui Yang7Xin Li8Xiaoming Lyu9Shenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre (CIRC), Shenzhen Hospital of Southern Medical University, Shenzhen 518100, ChinaShenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre (CIRC), Shenzhen Hospital of Southern Medical University, Shenzhen 518100, ChinaDepartment of Radiation Oncology, Huadong Hospital, Fudan University, Shanghai 200040, ChinaShenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre (CIRC), Shenzhen Hospital of Southern Medical University, Shenzhen 518100, ChinaThe Third School of Clinical Medicine, Southern Medical University, Guangzhou 510630, ChinaShenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre (CIRC), Shenzhen Hospital of Southern Medical University, Shenzhen 518100, ChinaThe Third School of Clinical Medicine, Southern Medical University, Guangzhou 510630, ChinaShenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre (CIRC), Shenzhen Hospital of Southern Medical University, Shenzhen 518100, ChinaShenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre (CIRC), Shenzhen Hospital of Southern Medical University, Shenzhen 518100, ChinaThe Third School of Clinical Medicine, Southern Medical University, Guangzhou 510630, ChinaThis study aimed to develop a model using Epstein–Barr virus (EBV)-associated hub genes in order to predict the prognosis of nasopharyngeal carcinoma (NPC). Differential expression analysis, univariate regression analysis, and machine learning were performed in three microarray datasets (GSE2371, GSE12452, and GSE102349) collected from the GEO database. Three hundred and sixty-six EBV-DEGs were identified, 25 of which were found to be significantly associated with NPC prognosis. These 25 genes were used to classify NPC into two subtypes, and six genes (C16orf54, CD27, CD53, CRIP1, RARRES3, and TBC1D10C) were found to be hub genes in NPC related to immune infiltration and cell cycle regulation. It was shown that these genes could be used to predict the prognosis of NPC, with functions related to tumor proliferation and immune infiltration, making them potential therapeutic targets. The findings of this study could aid in the development of screening and prognostic methods for NPC based on EBV-related features.https://www.mdpi.com/1999-4915/15/9/1915Epstein–Barr virusnasopharyngeal carcinomaprognosishub genes |
| spellingShingle | Tengteng Ding Yuanbin Zhang Zhixuan Ren Ying Cong Jingyi Long Manli Peng Oluwasijibomi Damola Faleti Yinggui Yang Xin Li Xiaoming Lyu EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma Viruses Epstein–Barr virus nasopharyngeal carcinoma prognosis hub genes |
| title | EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma |
| title_full | EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma |
| title_fullStr | EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma |
| title_full_unstemmed | EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma |
| title_short | EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma |
| title_sort | ebv associated hub genes as potential biomarkers for predicting the prognosis of nasopharyngeal carcinoma |
| topic | Epstein–Barr virus nasopharyngeal carcinoma prognosis hub genes |
| url | https://www.mdpi.com/1999-4915/15/9/1915 |
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