Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer

Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer

Background: Integrin family are known as key gears in focal adhesion for triple-negative breast cancer (TNBC) metastasis. However, the integrin independent factor TLN1 remains vague in TNBC. Methods: Bioinformatics analysis was performed based on TCGA database and Shengjing Hospital cohort. Western...

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Bibliographic Details
Main Authors: Yixiao Zhang, Lisha Sun, Haonan Li, Liping Ai, Qingtian Ma, Xinbo Qiao, Jie Yang, Hao Zhang, Xunyan Ou, Yining Wang, Guanglei Chen, Jinqi Xue, Xudong Zhu, Yu Zhao, Yongliang Yang, Caigang Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
triple-negative breast cancer
TLN1
cell adhesion
small molecule
Online Access:https://elifesciences.org/articles/68481

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