Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure
Not just differential gene expression but also differential gene regulation in immune cells account for individual differences in the immune response. Authors show here by single-cell RNA-sequencing of peripheral blood mononuclear cells from a large cohort of genetically diverse individuals that gen...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30893-5 |
| _version_ | 1811248091390541824 |
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| author | Roy Oelen Dylan H. de Vries Harm Brugge M. Grace Gordon Martijn Vochteloo single-cell eQTLGen consortium BIOS Consortium Chun J. Ye Harm-Jan Westra Lude Franke Monique G. P. van der Wijst |
| author_facet | Roy Oelen Dylan H. de Vries Harm Brugge M. Grace Gordon Martijn Vochteloo single-cell eQTLGen consortium BIOS Consortium Chun J. Ye Harm-Jan Westra Lude Franke Monique G. P. van der Wijst |
| author_sort | Roy Oelen |
| collection | DOAJ |
| description | Not just differential gene expression but also differential gene regulation in immune cells account for individual differences in the immune response. Authors show here by single-cell RNA-sequencing of peripheral blood mononuclear cells from a large cohort of genetically diverse individuals that gene expression and regulatory changes in these cells depend on the context of and interactions between cell types, genetics, type of pathogen and time after exposure. |
| first_indexed | 2024-04-12T15:20:44Z |
| format | Article |
| id | doaj.art-a0900e4955844d238d355bfc06a2a975 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T15:20:44Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a0900e4955844d238d355bfc06a2a9752022-12-22T03:27:27ZengNature PortfolioNature Communications2041-17232022-06-0113111510.1038/s41467-022-30893-5Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposureRoy Oelen0Dylan H. de Vries1Harm Brugge2M. Grace Gordon3Martijn Vochteloo4single-cell eQTLGen consortiumBIOS ConsortiumChun J. Ye5Harm-Jan Westra6Lude Franke7Monique G. P. van der Wijst8Department of Genetics, University of Groningen, University Medical Center GroningenDepartment of Genetics, University of Groningen, University Medical Center GroningenDepartment of Genetics, University of Groningen, University Medical Center GroningenBiological and Medical Informatics Graduate Program, University of California San FranciscoDepartment of Genetics, University of Groningen, University Medical Center GroningenInstitute for Human Genetics, University of California San FranciscoDepartment of Genetics, University of Groningen, University Medical Center GroningenDepartment of Genetics, University of Groningen, University Medical Center GroningenDepartment of Genetics, University of Groningen, University Medical Center GroningenNot just differential gene expression but also differential gene regulation in immune cells account for individual differences in the immune response. Authors show here by single-cell RNA-sequencing of peripheral blood mononuclear cells from a large cohort of genetically diverse individuals that gene expression and regulatory changes in these cells depend on the context of and interactions between cell types, genetics, type of pathogen and time after exposure.https://doi.org/10.1038/s41467-022-30893-5 |
| spellingShingle | Roy Oelen Dylan H. de Vries Harm Brugge M. Grace Gordon Martijn Vochteloo single-cell eQTLGen consortium BIOS Consortium Chun J. Ye Harm-Jan Westra Lude Franke Monique G. P. van der Wijst Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure Nature Communications |
| title | Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure |
| title_full | Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure |
| title_fullStr | Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure |
| title_full_unstemmed | Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure |
| title_short | Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure |
| title_sort | single cell rna sequencing of peripheral blood mononuclear cells reveals widespread context specific gene expression regulation upon pathogenic exposure |
| url | https://doi.org/10.1038/s41467-022-30893-5 |
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