Neurosteroid [3α,5α]-3-hydroxy-pregnan-20-one enhances IL-10 production via endosomal TRIF-dependent TLR4 signaling pathway
BackgroundPrevious studies demonstrated the inhibitory effect of allopregnanolone (3α,5α-THP) on the activation of inflammatory toll-like receptor 4 (TLR4) signals in RAW264.7 macrophages and the brains of selectively bred alcohol-preferring (P) rats. In the current study, we investigated the impact...
Main Authors: | Irina Balan, Adelina Grusca, Todd K. O’Buckley, A. Leslie Morrow |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-12-01
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Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1299420/full |
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