Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions
Circular RNA (circRNAs), an important member of the non-coding RNA (ncRNA) family, are widely expressed in a variety of biological cells. Owing to their stable structures, sequence conservations, and cell- or tissue-specific expressions, these RNA have become a popular subject of scientific research...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1031802/full |
| _version_ | 1811179911722827776 |
|---|---|
| author | Bowen Liu Chengbin Dong Quan Chen Zhenhua Fan Yu Zhang Yifan Wu Ting Cui Fuquan Liu |
| author_facet | Bowen Liu Chengbin Dong Quan Chen Zhenhua Fan Yu Zhang Yifan Wu Ting Cui Fuquan Liu |
| author_sort | Bowen Liu |
| collection | DOAJ |
| description | Circular RNA (circRNAs), an important member of the non-coding RNA (ncRNA) family, are widely expressed in a variety of biological cells. Owing to their stable structures, sequence conservations, and cell- or tissue-specific expressions, these RNA have become a popular subject of scientific research. With the development of sequencing methods, it has been revealed that circRNAs exert their biological function by sponging microRNAs (miRNAs), regulating transcription, or binding to proteins. Humans have historically been significantly impacted by various types of cancer. Studies have shown that circRNAs are abnormally expressed in various cancers and are involved in the occurrence and development of malignant tumors, such as tumor cell proliferation, migration, and invasion. As one of its star molecules, circ_0007534 is upregulated in colorectal, cervical, and pancreatic cancers; is closely related to the occurrence, development, and prognosis of tumors; and is expected to become a novel tumor marker and therapeutic target. This article briefly reviews the expression and mechanism of circ_0007534 in malignant tumors based on the domestic and foreign literature. |
| first_indexed | 2024-04-11T06:42:43Z |
| format | Article |
| id | doaj.art-a0920bed8a004cf2bf58b83e2a5fd954 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T06:42:43Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a0920bed8a004cf2bf58b83e2a5fd9542022-12-22T04:39:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10318021031802Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactionsBowen LiuChengbin DongQuan ChenZhenhua FanYu ZhangYifan WuTing CuiFuquan LiuCircular RNA (circRNAs), an important member of the non-coding RNA (ncRNA) family, are widely expressed in a variety of biological cells. Owing to their stable structures, sequence conservations, and cell- or tissue-specific expressions, these RNA have become a popular subject of scientific research. With the development of sequencing methods, it has been revealed that circRNAs exert their biological function by sponging microRNAs (miRNAs), regulating transcription, or binding to proteins. Humans have historically been significantly impacted by various types of cancer. Studies have shown that circRNAs are abnormally expressed in various cancers and are involved in the occurrence and development of malignant tumors, such as tumor cell proliferation, migration, and invasion. As one of its star molecules, circ_0007534 is upregulated in colorectal, cervical, and pancreatic cancers; is closely related to the occurrence, development, and prognosis of tumors; and is expected to become a novel tumor marker and therapeutic target. This article briefly reviews the expression and mechanism of circ_0007534 in malignant tumors based on the domestic and foreign literature.https://www.frontiersin.org/articles/10.3389/fonc.2022.1031802/fullcircRNAcirc_0007534tumorexpressionproliferationmigration |
| spellingShingle | Bowen Liu Chengbin Dong Quan Chen Zhenhua Fan Yu Zhang Yifan Wu Ting Cui Fuquan Liu Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions Frontiers in Oncology circRNA circ_0007534 tumor expression proliferation migration |
| title | Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions |
| title_full | Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions |
| title_fullStr | Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions |
| title_full_unstemmed | Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions |
| title_short | Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions |
| title_sort | circ 0007534 as new emerging target in cancer biological functions and molecular interactions |
| topic | circRNA circ_0007534 tumor expression proliferation migration |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1031802/full |
| work_keys_str_mv | AT bowenliu circ0007534asnewemergingtargetincancerbiologicalfunctionsandmolecularinteractions AT chengbindong circ0007534asnewemergingtargetincancerbiologicalfunctionsandmolecularinteractions AT quanchen circ0007534asnewemergingtargetincancerbiologicalfunctionsandmolecularinteractions AT zhenhuafan circ0007534asnewemergingtargetincancerbiologicalfunctionsandmolecularinteractions AT yuzhang circ0007534asnewemergingtargetincancerbiologicalfunctionsandmolecularinteractions AT yifanwu circ0007534asnewemergingtargetincancerbiologicalfunctionsandmolecularinteractions AT tingcui circ0007534asnewemergingtargetincancerbiologicalfunctionsandmolecularinteractions AT fuquanliu circ0007534asnewemergingtargetincancerbiologicalfunctionsandmolecularinteractions |