Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systems
In this study, glucomannan-poly(acrylic acid) hydrogels were synthesized under different conditions. The hydrogels consist of glucomannan and acrylic acid and are crosslinked by N,N-methylene-bis-(acrylamide). The structure and morphology of the hydrogels were investigated by using Fourier-transfor...
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| Format: | Article |
| Language: | English |
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HUJOS
2022-03-01
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| Series: | Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên |
| Subjects: | |
| Online Access: | http://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/6637 |
| _version_ | 1818537506771042304 |
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| author | Lam Son Le Thuy Trang Le Thi Van Thi Tran Vinh Phu Nguyen Quang Man Nguyen Trung Hieu Le |
| author_facet | Lam Son Le Thuy Trang Le Thi Van Thi Tran Vinh Phu Nguyen Quang Man Nguyen Trung Hieu Le |
| author_sort | Lam Son Le |
| collection | DOAJ |
| description |
In this study, glucomannan-poly(acrylic acid) hydrogels were synthesized under different conditions. The hydrogels consist of glucomannan and acrylic acid and are crosslinked by N,N-methylene-bis-(acrylamide). The structure and morphology of the hydrogels were investigated by using Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM). The swelling ratio, biodegradation and pH-sensitive properties, relationship between hydrogel swelling rate and 5-ASA adsorption-desorption capacity, influence of medium pH on 5-ASA desorption, and 5-ASA adsorption kinetics were studied. The swelling ratio of the synthesized hydrogel samples is 16.70–56.21 times. This ratio is low in the pH 1.0 media and increases significantly in the pH 7,4 media. The hydrogels are biodegradable in the presence of cellulase (400 U·mg–1) in a pH 7.4 phosphate buffer at 37 °C (69.8% after ten days; the cellulase concentration 1.5 g·L–1). The hydrogels exhibit high adsorption and desorption capacities for 5-ASA. The adsorption kinetics follows the pseudo-first-order model. These hydrogels can be applied to smart drug delivery systems.
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| first_indexed | 2024-12-11T18:51:37Z |
| format | Article |
| id | doaj.art-a097b69e823c4feabde96a966c771b1f |
| institution | Directory Open Access Journal |
| issn | 1859-1388 2615-9678 |
| language | English |
| last_indexed | 2024-12-11T18:51:37Z |
| publishDate | 2022-03-01 |
| publisher | HUJOS |
| record_format | Article |
| series | Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên |
| spelling | doaj.art-a097b69e823c4feabde96a966c771b1f2022-12-22T00:54:16ZengHUJOSTạp chí Khoa học Đại học Huế: Khoa học Tự nhiên1859-13882615-96782022-03-011311A10.26459/hueunijns.v131i1A.6637Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systemsLam Son Le0Thuy Trang Le1Thi Van Thi Tran2Vinh Phu Nguyen3Quang Man Nguyen4Trung Hieu Le5University of Sciences, Hue University, 77 Nguyen Hue St., Hue, VietnamUniversity of Sciences, Hue University, 77 Nguyen Hue St., Hue, VietnamUniversity of Sciences, Hue University, 77 Nguyen Hue St., Hue, VietnamUniversity of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, VietnamUniversity of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, VietnamUniversity of Sciences, Hue University, 77 Nguyen Hue St., Hue, Vietnam In this study, glucomannan-poly(acrylic acid) hydrogels were synthesized under different conditions. The hydrogels consist of glucomannan and acrylic acid and are crosslinked by N,N-methylene-bis-(acrylamide). The structure and morphology of the hydrogels were investigated by using Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM). The swelling ratio, biodegradation and pH-sensitive properties, relationship between hydrogel swelling rate and 5-ASA adsorption-desorption capacity, influence of medium pH on 5-ASA desorption, and 5-ASA adsorption kinetics were studied. The swelling ratio of the synthesized hydrogel samples is 16.70–56.21 times. This ratio is low in the pH 1.0 media and increases significantly in the pH 7,4 media. The hydrogels are biodegradable in the presence of cellulase (400 U·mg–1) in a pH 7.4 phosphate buffer at 37 °C (69.8% after ten days; the cellulase concentration 1.5 g·L–1). The hydrogels exhibit high adsorption and desorption capacities for 5-ASA. The adsorption kinetics follows the pseudo-first-order model. These hydrogels can be applied to smart drug delivery systems. http://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/6637drug delivery systempH-sensitivehydrogel |
| spellingShingle | Lam Son Le Thuy Trang Le Thi Van Thi Tran Vinh Phu Nguyen Quang Man Nguyen Trung Hieu Le Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systems Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên drug delivery system pH-sensitive hydrogel |
| title | Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systems |
| title_full | Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systems |
| title_fullStr | Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systems |
| title_full_unstemmed | Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systems |
| title_short | Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systems |
| title_sort | synthesis and characterization of ph sensitive glucomannan poly acrylic acid hydrogels for 5 aminosalicylic acid controlled delivery systems |
| topic | drug delivery system pH-sensitive hydrogel |
| url | http://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/6637 |
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