Non-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case report
Abstract Background Cryptococcosis is one of the most frequent fungal eye infections in patients with immunosuppression. Currently, treatment approaches for non-meningeal, non-pulmonary cryptococcosis are based on those used for cryptococcal meningitis or pneumonia. Case presentation We present a ra...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-023-03130-w |
| _version_ | 1797453491649642496 |
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| author | Yi-An Lu Chun-Hsien Lin Chia-Jen Chang Kuo-Hsiung Shu Mu-Chi Chung Chien-Chih Chou |
| author_facet | Yi-An Lu Chun-Hsien Lin Chia-Jen Chang Kuo-Hsiung Shu Mu-Chi Chung Chien-Chih Chou |
| author_sort | Yi-An Lu |
| collection | DOAJ |
| description | Abstract Background Cryptococcosis is one of the most frequent fungal eye infections in patients with immunosuppression. Currently, treatment approaches for non-meningeal, non-pulmonary cryptococcosis are based on those used for cryptococcal meningitis or pneumonia. Case presentation We present a rare case of non-meningeal, non-pulmonary cryptococcosis with clinical manifestations limited to one eye of a cadaveric kidney transplant recipient with chronic-active antibody-mediated rejection. Typical manifestations, diagnosis, and treatments, including antifungal therapies, adjunctive therapies, and immunosuppression reduction, are discussed. After timely diagnosis and treatment, her visual acuity recovered to baseline without recurrence or sequelae of cryptococcosis. Conclusions Clinicians should be aware of rare presentations of fungal infections, especially when a kidney transplant recipient with rejection has been treated with intensive immunosuppressants. Early diagnosis with individualized therapies may have a favorable prognosis. |
| first_indexed | 2024-03-09T15:23:36Z |
| format | Article |
| id | doaj.art-a09812e8896d4c48b24d776b823964bc |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-09T15:23:36Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-a09812e8896d4c48b24d776b823964bc2023-11-26T12:39:51ZengBMCBMC Ophthalmology1471-24152023-10-012311710.1186/s12886-023-03130-wNon-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case reportYi-An Lu0Chun-Hsien Lin1Chia-Jen Chang2Kuo-Hsiung Shu3Mu-Chi Chung4Chien-Chih Chou5Department of Ophthalmology, Taichung Veterans General HospitalDepartment of Ophthalmology, Taichung Veterans General HospitalDepartment of Ophthalmology, Taichung Veterans General HospitalDivision of Nephrology, Department of Internal Medicine, Lin Shin HospitalDivision of Nephrology, Department of Medicine, Taichung Veterans General HospitalDepartment of Ophthalmology, Taichung Veterans General HospitalAbstract Background Cryptococcosis is one of the most frequent fungal eye infections in patients with immunosuppression. Currently, treatment approaches for non-meningeal, non-pulmonary cryptococcosis are based on those used for cryptococcal meningitis or pneumonia. Case presentation We present a rare case of non-meningeal, non-pulmonary cryptococcosis with clinical manifestations limited to one eye of a cadaveric kidney transplant recipient with chronic-active antibody-mediated rejection. Typical manifestations, diagnosis, and treatments, including antifungal therapies, adjunctive therapies, and immunosuppression reduction, are discussed. After timely diagnosis and treatment, her visual acuity recovered to baseline without recurrence or sequelae of cryptococcosis. Conclusions Clinicians should be aware of rare presentations of fungal infections, especially when a kidney transplant recipient with rejection has been treated with intensive immunosuppressants. Early diagnosis with individualized therapies may have a favorable prognosis.https://doi.org/10.1186/s12886-023-03130-wCryptococcal infectionSolid organ transplantKidney transplantDouble filtration plasmapheresisImmunosuppressantUveitis |
| spellingShingle | Yi-An Lu Chun-Hsien Lin Chia-Jen Chang Kuo-Hsiung Shu Mu-Chi Chung Chien-Chih Chou Non-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case report BMC Ophthalmology Cryptococcal infection Solid organ transplant Kidney transplant Double filtration plasmapheresis Immunosuppressant Uveitis |
| title | Non-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case report |
| title_full | Non-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case report |
| title_fullStr | Non-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case report |
| title_full_unstemmed | Non-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case report |
| title_short | Non-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case report |
| title_sort | non meningeal non pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody mediated rejection a case report |
| topic | Cryptococcal infection Solid organ transplant Kidney transplant Double filtration plasmapheresis Immunosuppressant Uveitis |
| url | https://doi.org/10.1186/s12886-023-03130-w |
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