Immune Checkpoint Blockade Enhances Immune Activity of Therapeutic Lung Cancer Vaccine

Immune Checkpoint Blockade Enhances Immune Activity of Therapeutic Lung Cancer Vaccine

Background: Immune checkpoint blockade that downregulates T cell evasion for effective immunity has provided a renewed interest in therapeutic cancer vaccines. Methods: Utilizing murine lung cancer models, we determined: tumor burden, TIL cytolysis, immunohistochemistry, flow cytometry, RNA Sequenci...

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Bibliographic Details
Main Authors:	Pournima Kadam, Ram P. Singh, Michael Davoodi, Jay M. Lee, Maie St. John, Sherven Sharma
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Series:	Vaccines
Subjects:	lung cancer PD-1 CCL21 dendritic cells (DC) T cells tumor microenvironment (TME)
Online Access:	https://www.mdpi.com/2076-393X/8/4/655

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