Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model
Non-alcoholic fatty liver disease (NAFLD) is a substantial global health issue owing to its high prevalence and the lack of effective therapies. Fermentation of medicinal herbs has always been considered a feasible strategy for enhancing efficacy in treating various ailments. This study aimed to inv...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224001318 |
| _version_ | 1797291846966181888 |
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| author | Seung-Ju Hwang Yu-Jin Choi Jing-Hua Wang Chang-Gue Son |
| author_facet | Seung-Ju Hwang Yu-Jin Choi Jing-Hua Wang Chang-Gue Son |
| author_sort | Seung-Ju Hwang |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is a substantial global health issue owing to its high prevalence and the lack of effective therapies. Fermentation of medicinal herbs has always been considered a feasible strategy for enhancing efficacy in treating various ailments. This study aimed to investigate the potential benefits of the Lactobacillus casei-fermented Amomum xanthioides (LAX) on NAFLD in a high-fat diet model. HFD-fed C57BL6/j mice were administered with 200 mg/kg of LAX or unfermented Amomum xanthioides (AX) or 100 mg/kg of metformin for 6 weeks from the 4th week. The 10-week HFD-induced alterations of hepatic lipid accumulation and hepatic inflammation were significantly attenuated by LAX dominantly (more than AX or metformin), which evidenced by pathohistological findings, lipid contents, inflammatory cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)− 6 and IL-1β, oxidative parameters such as reactive oxygen species (ROS) and malondialdehyde (MDA), and molecular changes reversely between lipogenic proteins such as glycerol-3-phosphate acyltransferase (GPAM) and sterol regulatory element-binding protein (SREBP)− 1, and lipolytic proteins including peroxisome proliferator-activated receptor (PPAR-α) and AMP-activated kinase (AMPK)-α in the liver tissues. In addition, the abnormal serum lipid parameters (triglyceride, total cholesterol and LDL-cholesterol) notably ameliorated by LAX. In conclusion, these findings support the potential of LAX as a promising plant-derived remedy for NAFLD. |
| first_indexed | 2024-03-07T19:43:40Z |
| format | Article |
| id | doaj.art-a09a652714444bc0b470ab3d6a3b928f |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-07T19:43:40Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-a09a652714444bc0b470ab3d6a3b928f2024-02-29T05:17:53ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-03-01172116250Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice modelSeung-Ju Hwang0Yu-Jin Choi1Jing-Hua Wang2Chang-Gue Son3Institute of Bioscience & Integrative Medicine, Daejeon University, 75, Daedukdae-ro 176 bun-gil, Seo-gu, Daejeon 35235, the Republic of Korea; Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 75, Daedukdae-ro 176 bun-gil, Seo-gu, Daejeon 35235, the Republic of KoreaInstitute of Bioscience & Integrative Medicine, Daejeon University, 75, Daedukdae-ro 176 bun-gil, Seo-gu, Daejeon 35235, the Republic of Korea; Department of Internal Medicine, College of Korean Medicine, Se-Myung University, Semyeong-ro 65, Jecheon-si, Chungcheongbuk-do, 27136, the Republic of KoreaInstitute of Bioscience & Integrative Medicine, Daejeon University, 75, Daedukdae-ro 176 bun-gil, Seo-gu, Daejeon 35235, the Republic of Korea; Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 75, Daedukdae-ro 176 bun-gil, Seo-gu, Daejeon 35235, the Republic of Korea; Corresponding authors at: Institute of Bioscience & Integrative Medicine, Daejeon University, 75, Daedukdae-ro 176 bun-gil, Seo-gu, Daejeon 35235, the Republic of Korea.Institute of Bioscience & Integrative Medicine, Daejeon University, 75, Daedukdae-ro 176 bun-gil, Seo-gu, Daejeon 35235, the Republic of Korea; Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 75, Daedukdae-ro 176 bun-gil, Seo-gu, Daejeon 35235, the Republic of Korea; Corresponding authors at: Institute of Bioscience & Integrative Medicine, Daejeon University, 75, Daedukdae-ro 176 bun-gil, Seo-gu, Daejeon 35235, the Republic of Korea.Non-alcoholic fatty liver disease (NAFLD) is a substantial global health issue owing to its high prevalence and the lack of effective therapies. Fermentation of medicinal herbs has always been considered a feasible strategy for enhancing efficacy in treating various ailments. This study aimed to investigate the potential benefits of the Lactobacillus casei-fermented Amomum xanthioides (LAX) on NAFLD in a high-fat diet model. HFD-fed C57BL6/j mice were administered with 200 mg/kg of LAX or unfermented Amomum xanthioides (AX) or 100 mg/kg of metformin for 6 weeks from the 4th week. The 10-week HFD-induced alterations of hepatic lipid accumulation and hepatic inflammation were significantly attenuated by LAX dominantly (more than AX or metformin), which evidenced by pathohistological findings, lipid contents, inflammatory cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)− 6 and IL-1β, oxidative parameters such as reactive oxygen species (ROS) and malondialdehyde (MDA), and molecular changes reversely between lipogenic proteins such as glycerol-3-phosphate acyltransferase (GPAM) and sterol regulatory element-binding protein (SREBP)− 1, and lipolytic proteins including peroxisome proliferator-activated receptor (PPAR-α) and AMP-activated kinase (AMPK)-α in the liver tissues. In addition, the abnormal serum lipid parameters (triglyceride, total cholesterol and LDL-cholesterol) notably ameliorated by LAX. In conclusion, these findings support the potential of LAX as a promising plant-derived remedy for NAFLD.http://www.sciencedirect.com/science/article/pii/S0753332224001318Non-alcoholic fatty liver diseaseAmomum xanthioidesLactobacillus caseiFermentationOxidative stress |
| spellingShingle | Seung-Ju Hwang Yu-Jin Choi Jing-Hua Wang Chang-Gue Son Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model Biomedicine & Pharmacotherapy Non-alcoholic fatty liver disease Amomum xanthioides Lactobacillus casei Fermentation Oxidative stress |
| title | Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model |
| title_full | Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model |
| title_fullStr | Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model |
| title_full_unstemmed | Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model |
| title_short | Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model |
| title_sort | lactobacillus casei fermented amomum xanthioides mitigates non alcoholic fatty liver disease in a high fat diet mice model |
| topic | Non-alcoholic fatty liver disease Amomum xanthioides Lactobacillus casei Fermentation Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224001318 |
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