Diagnosis in Scrapie: Conventional Methods and New Biomarkers
Scrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical and atypical forms, with classical scrapie being the archetype of transmissible spongiform encephalopathies. This review explores the challenges of scrapie diagnosis and the utility of various biomarkers and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/12/1399 |
| _version_ | 1827573864122548224 |
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| author | Diego Sola Marina Betancor Paula A. Marco Lorente Sonia Pérez Lázaro Tomás Barrio Eloisa Sevilla Belén Marín Bernardino Moreno Marta Monzón Cristina Acín Rosa Bolea Juan J. Badiola Alicia Otero |
| author_facet | Diego Sola Marina Betancor Paula A. Marco Lorente Sonia Pérez Lázaro Tomás Barrio Eloisa Sevilla Belén Marín Bernardino Moreno Marta Monzón Cristina Acín Rosa Bolea Juan J. Badiola Alicia Otero |
| author_sort | Diego Sola |
| collection | DOAJ |
| description | Scrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical and atypical forms, with classical scrapie being the archetype of transmissible spongiform encephalopathies. This review explores the challenges of scrapie diagnosis and the utility of various biomarkers and their potential implications for human prion diseases. Understanding these biomarkers in the context of scrapie may enable earlier prion disease diagnosis in humans, which is crucial for effective intervention. Research on scrapie biomarkers bridges the gap between veterinary and human medicine, offering hope for the early detection and improved management of prion diseases. |
| first_indexed | 2024-03-08T20:28:14Z |
| format | Article |
| id | doaj.art-a09a68ca32cc40e7afbfe4f4d56f9e1e |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-08T20:28:14Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-a09a68ca32cc40e7afbfe4f4d56f9e1e2023-12-22T14:30:49ZengMDPI AGPathogens2076-08172023-11-011212139910.3390/pathogens12121399Diagnosis in Scrapie: Conventional Methods and New BiomarkersDiego Sola0Marina Betancor1Paula A. Marco Lorente2Sonia Pérez Lázaro3Tomás Barrio4Eloisa Sevilla5Belén Marín6Bernardino Moreno7Marta Monzón8Cristina Acín9Rosa Bolea10Juan J. Badiola11Alicia Otero12Centro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainUnité Mixte de Recherche de l’Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement1225 Interactions Hôtes-Agents Pathogènes, École Nationale Vétérinaire de Toulouse, 31076 Toulouse, FranceCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Facultad de Veterinaria, IA2, Universidad de Zaragoza, 50013 Zaragoza, SpainScrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical and atypical forms, with classical scrapie being the archetype of transmissible spongiform encephalopathies. This review explores the challenges of scrapie diagnosis and the utility of various biomarkers and their potential implications for human prion diseases. Understanding these biomarkers in the context of scrapie may enable earlier prion disease diagnosis in humans, which is crucial for effective intervention. Research on scrapie biomarkers bridges the gap between veterinary and human medicine, offering hope for the early detection and improved management of prion diseases.https://www.mdpi.com/2076-0817/12/12/1399scrapieprion diseasesPrPScprion biomarkers |
| spellingShingle | Diego Sola Marina Betancor Paula A. Marco Lorente Sonia Pérez Lázaro Tomás Barrio Eloisa Sevilla Belén Marín Bernardino Moreno Marta Monzón Cristina Acín Rosa Bolea Juan J. Badiola Alicia Otero Diagnosis in Scrapie: Conventional Methods and New Biomarkers Pathogens scrapie prion diseases PrPSc prion biomarkers |
| title | Diagnosis in Scrapie: Conventional Methods and New Biomarkers |
| title_full | Diagnosis in Scrapie: Conventional Methods and New Biomarkers |
| title_fullStr | Diagnosis in Scrapie: Conventional Methods and New Biomarkers |
| title_full_unstemmed | Diagnosis in Scrapie: Conventional Methods and New Biomarkers |
| title_short | Diagnosis in Scrapie: Conventional Methods and New Biomarkers |
| title_sort | diagnosis in scrapie conventional methods and new biomarkers |
| topic | scrapie prion diseases PrPSc prion biomarkers |
| url | https://www.mdpi.com/2076-0817/12/12/1399 |
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