Carnosic Acid against Lung Cancer: Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling

Carnosic Acid against Lung Cancer: Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling

Non-small cell lung cancer (NSCLC) represents 80% of all lung cancer cases and is characterized by low survival rates due to chemotherapy and radiation resistance. Novel treatment strategies for NSCLC are urgently needed. Liver kinase B1 (LKB1), a tumor suppressor prevalently mutated in NSCLC, activ...

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Bibliographic Details
Main Authors: Eric J. O’Neill, Newman Siu Kwan Sze, Rebecca E. K. MacPherson, Evangelia Tsiani
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
NSCLC
carnosic acid
autophagy
apoptosis
polyphenols
lung cancer
Online Access:https://www.mdpi.com/1422-0067/25/4/1950

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