Determination of genetic correlation between tobacco smoking and coronary artery disease
BackgroundsTobacco smoking is an important risk factor for coronary artery disease (CAD), but the genetic mechanisms linking smoking to CAD remain largely unknown.MethodsWe analyzed summary data from the genome-wide association study (GWAS) of the UK Biobank for CAD, plasma lipid concentrations (n =...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1279962/full |
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| author | Zhouhai Zhu Qiang Liu Meng Li Yinghao Yao Feiyan Qi Yi Xu Sheming Lu Zhongli Yang Ying Guan Ming D. Li Jianhua Yao |
| author_facet | Zhouhai Zhu Qiang Liu Meng Li Yinghao Yao Feiyan Qi Yi Xu Sheming Lu Zhongli Yang Ying Guan Ming D. Li Jianhua Yao |
| author_sort | Zhouhai Zhu |
| collection | DOAJ |
| description | BackgroundsTobacco smoking is an important risk factor for coronary artery disease (CAD), but the genetic mechanisms linking smoking to CAD remain largely unknown.MethodsWe analyzed summary data from the genome-wide association study (GWAS) of the UK Biobank for CAD, plasma lipid concentrations (n = 184,305), and smoking (n = 337,030) using different biostatistical methods, which included LD score regression and Mendelian randomization (MR).ResultsWe identified SNPs shared by CAD and at least one smoking behavior, the genes where these SNPs are located were found to be significantly enriched in the processes related to lipoprotein metabolic, chylomicron-mediated lipid transport, lipid digestion, mobilization, and transport. The MR analysis revealed a positive correlation between smoking cessation and decreased risk for CAD when smoking cessation was considered as exposure (p = 0.001), and a negative correlation between the increased risk for CAD and smoking cessation when CAD was considered as exposure (p = 2.95E-08). This analysis further indicated that genetic liability for smoking cessation increased the risk of CAD.ConclusionThese findings inform the concomitant conditions of CAD and smoking and support the idea that genetic liabilities for smoking behaviors are strongly associated with the risk of CAD. |
| first_indexed | 2024-03-11T21:30:04Z |
| format | Article |
| id | doaj.art-a09fd6b4ff7a4691a55eb1988ca10504 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-11T21:30:04Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-a09fd6b4ff7a4691a55eb1988ca105042023-09-27T10:05:41ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-09-011410.3389/fpsyt.2023.12799621279962Determination of genetic correlation between tobacco smoking and coronary artery diseaseZhouhai Zhu0Qiang Liu1Meng Li2Yinghao Yao3Feiyan Qi4Yi Xu5Sheming Lu6Zhongli Yang7Ying Guan8Ming D. Li9Jianhua Yao10Joint Institute of Tobacco and Health, Kunming, Yunnan, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaJoint Institute of Tobacco and Health, Kunming, Yunnan, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaJoint Institute of Tobacco and Health, Kunming, Yunnan, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaJoint Institute of Tobacco and Health, Kunming, Yunnan, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaJoint Institute of Tobacco and Health, Kunming, Yunnan, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaJoint Institute of Tobacco and Health, Kunming, Yunnan, ChinaBackgroundsTobacco smoking is an important risk factor for coronary artery disease (CAD), but the genetic mechanisms linking smoking to CAD remain largely unknown.MethodsWe analyzed summary data from the genome-wide association study (GWAS) of the UK Biobank for CAD, plasma lipid concentrations (n = 184,305), and smoking (n = 337,030) using different biostatistical methods, which included LD score regression and Mendelian randomization (MR).ResultsWe identified SNPs shared by CAD and at least one smoking behavior, the genes where these SNPs are located were found to be significantly enriched in the processes related to lipoprotein metabolic, chylomicron-mediated lipid transport, lipid digestion, mobilization, and transport. The MR analysis revealed a positive correlation between smoking cessation and decreased risk for CAD when smoking cessation was considered as exposure (p = 0.001), and a negative correlation between the increased risk for CAD and smoking cessation when CAD was considered as exposure (p = 2.95E-08). This analysis further indicated that genetic liability for smoking cessation increased the risk of CAD.ConclusionThese findings inform the concomitant conditions of CAD and smoking and support the idea that genetic liabilities for smoking behaviors are strongly associated with the risk of CAD.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1279962/fullsmokingCADcoronary artery diseasegenome-wide association studymendelian randomization analysis |
| spellingShingle | Zhouhai Zhu Qiang Liu Meng Li Yinghao Yao Feiyan Qi Yi Xu Sheming Lu Zhongli Yang Ying Guan Ming D. Li Jianhua Yao Determination of genetic correlation between tobacco smoking and coronary artery disease Frontiers in Psychiatry smoking CAD coronary artery disease genome-wide association study mendelian randomization analysis |
| title | Determination of genetic correlation between tobacco smoking and coronary artery disease |
| title_full | Determination of genetic correlation between tobacco smoking and coronary artery disease |
| title_fullStr | Determination of genetic correlation between tobacco smoking and coronary artery disease |
| title_full_unstemmed | Determination of genetic correlation between tobacco smoking and coronary artery disease |
| title_short | Determination of genetic correlation between tobacco smoking and coronary artery disease |
| title_sort | determination of genetic correlation between tobacco smoking and coronary artery disease |
| topic | smoking CAD coronary artery disease genome-wide association study mendelian randomization analysis |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1279962/full |
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