Tacrolimus-induced optic neuropathy: A case report
Intrduction. Tacrolimus (fujimycin or FK506) is a potent immunosuppressive drug with growing usage. It is usually used in prevention of transplanted organ rejection. Its use is highly valuable, but like other immunosupressants, it has adverse effects. One of them is optic neuropathy. Cas...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2022-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100004Z.pdf |
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| author | Žorić Lepša Ilić Aleksandra Čolak Emina Mirković Miloš Pantelić Jelica Mirić Dijana Kisić Bojana |
| author_facet | Žorić Lepša Ilić Aleksandra Čolak Emina Mirković Miloš Pantelić Jelica Mirić Dijana Kisić Bojana |
| author_sort | Žorić Lepša |
| collection | DOAJ |
| description | Intrduction. Tacrolimus (fujimycin or FK506) is a potent immunosuppressive
drug with growing usage. It is usually used in prevention of transplanted
organ rejection. Its use is highly valuable, but like other
immunosupressants, it has adverse effects. One of them is optic neuropathy.
Case report. A 47-year-old white male patients who had received tacrolimus
therapy for nine years, after kidney transplantation, developed a subacute,
painless vision loss on both eyes. He was thoroughly examined on different
possible optic neuropathies and other causes of vision loss. After exclusion
of other possible causes, the diagnosis of toxic optic neuropathy was
established. His therapy was converted to cyclosporine, by his nephrologist,
but his vision had improved only slightly. Conclusion. Toxic optic
neuropathies are presented in everyday ophthalmological practice, but they
are underestimated. Diagnosis can be demanding, especially when it comes to
drugs and substances whose possible toxic effect on the optic nerve is not
widely known. Unlike other adverse effects of tacrolimus therapy on nervous
system, optic neuropathy can causes great and permanent functional
impairment. |
| first_indexed | 2024-12-11T16:17:24Z |
| format | Article |
| id | doaj.art-a0a088237d9c4f639c06fcd3b79e4e49 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-11T16:17:24Z |
| publishDate | 2022-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-a0a088237d9c4f639c06fcd3b79e4e492022-12-22T00:58:56ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202022-01-0179661962310.2298/VSP201126004Z0042-84502100004ZTacrolimus-induced optic neuropathy: A case reportŽorić Lepša0Ilić Aleksandra1Čolak Emina2Mirković Miloš3Pantelić Jelica4Mirić Dijana5Kisić Bojana6https://orcid.org/0000-0002-3018-1186University of Priština, Faculty of Medicine, Ophthalmology Department, Kosovska Mitrovica, Serbia + University Clinical Center of Serbia, Institute of Eye Diseases, Belgrade, SerbiaUniversity Clinical Center of Serbia, Institute of Eye Diseases, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Center of Serbia, Institute of Medical Biochemistry, Belgrade, SerbiaUniversity of Priština, Faculty of Medicine, Ophthalmology Department, Kosovska Mitrovica, SerbiaUniversity Clinical Center of Serbia, Institute of Eye Diseases, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity of Priština, Faculty of Medicine, Institute of Medical Biochemistry, Kosovska Mitrovica, SerbiaUniversity of Priština, Faculty of Medicine, Institute of Medical Biochemistry, Kosovska Mitrovica, SerbiaIntrduction. Tacrolimus (fujimycin or FK506) is a potent immunosuppressive drug with growing usage. It is usually used in prevention of transplanted organ rejection. Its use is highly valuable, but like other immunosupressants, it has adverse effects. One of them is optic neuropathy. Case report. A 47-year-old white male patients who had received tacrolimus therapy for nine years, after kidney transplantation, developed a subacute, painless vision loss on both eyes. He was thoroughly examined on different possible optic neuropathies and other causes of vision loss. After exclusion of other possible causes, the diagnosis of toxic optic neuropathy was established. His therapy was converted to cyclosporine, by his nephrologist, but his vision had improved only slightly. Conclusion. Toxic optic neuropathies are presented in everyday ophthalmological practice, but they are underestimated. Diagnosis can be demanding, especially when it comes to drugs and substances whose possible toxic effect on the optic nerve is not widely known. Unlike other adverse effects of tacrolimus therapy on nervous system, optic neuropathy can causes great and permanent functional impairment.http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100004Z.pdfdrug-related side effects and adverse reactionstacrolimustoxic optic neuropathytreatment outcome |
| spellingShingle | Žorić Lepša Ilić Aleksandra Čolak Emina Mirković Miloš Pantelić Jelica Mirić Dijana Kisić Bojana Tacrolimus-induced optic neuropathy: A case report Vojnosanitetski Pregled drug-related side effects and adverse reactions tacrolimus toxic optic neuropathy treatment outcome |
| title | Tacrolimus-induced optic neuropathy: A case report |
| title_full | Tacrolimus-induced optic neuropathy: A case report |
| title_fullStr | Tacrolimus-induced optic neuropathy: A case report |
| title_full_unstemmed | Tacrolimus-induced optic neuropathy: A case report |
| title_short | Tacrolimus-induced optic neuropathy: A case report |
| title_sort | tacrolimus induced optic neuropathy a case report |
| topic | drug-related side effects and adverse reactions tacrolimus toxic optic neuropathy treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100004Z.pdf |
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