Nomogram for individually predicting overall survival in rectal neuroendocrine tumours
Abstract Background This study aimed to develop a nomogram that predicts the overall survival (OS) of rectal neuroendocrine tumours (NETs). Methods We retrospectively analysed 310 patients with rectal neuroendocrine tumours in 5 hospitals in southern China. All of the patients were assigned to the t...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-09-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12885-020-07328-9 |
| _version_ | 1819207871874727936 |
|---|---|
| author | Xingyu Feng Gengzhou Wei Wei Wang Yu Zhang Yujie Zeng Minhu Chen Ye Chen Jie Chen Zhiwei Zhou Yong Li |
| author_facet | Xingyu Feng Gengzhou Wei Wei Wang Yu Zhang Yujie Zeng Minhu Chen Ye Chen Jie Chen Zhiwei Zhou Yong Li |
| author_sort | Xingyu Feng |
| collection | DOAJ |
| description | Abstract Background This study aimed to develop a nomogram that predicts the overall survival (OS) of rectal neuroendocrine tumours (NETs). Methods We retrospectively analysed 310 patients with rectal neuroendocrine tumours in 5 hospitals in southern China. All of the patients were assigned to the training set. A multivariable analysis using Cox proportional hazards regression was performed using the training set, and a nomogram was constructed. It was validated on a dataset obtained from the Surveillance, Epidemiology, and End Result (SEER) database of America (n = 547). Results In the training set, the nomogram exhibited improved discrimination power compared with the WHO grade guidelines (Herrell’s C-index, 0.872 vs 0.794; p < 0.001) and was also better than the seventh AJCC TNM classification (Herrell’s C-index, 0.872 vs 0.817; p < 0.001). In the SEER validation dataset, the discrimination was also excellent (C-index, 0.648 vs 0.583, p < 0.001 and 0.648 vs 0.603, p = 0.016, respectively, compared with G grade and TNM classification). Calibration of the nomogram predicted individual survival corresponding closely with the actual survival. Conclusions We developed a nomogram predicting 1- and 3-year OS of patients with rectal neuroendocrine tumours. Validation revealed excellent discrimination and calibration, suggesting good clinical utility. |
| first_indexed | 2024-12-23T05:30:23Z |
| format | Article |
| id | doaj.art-a0a11ca25d454921b4ed95e8d8f5a774 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-23T05:30:23Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-a0a11ca25d454921b4ed95e8d8f5a7742022-12-21T17:58:29ZengBMCBMC Cancer1471-24072020-09-012011710.1186/s12885-020-07328-9Nomogram for individually predicting overall survival in rectal neuroendocrine tumoursXingyu Feng0Gengzhou Wei1Wei Wang2Yu Zhang3Yujie Zeng4Minhu Chen5Ye Chen6Jie Chen7Zhiwei Zhou8Yong Li9Department of General Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, The Second School of Clinical Medicine, Southern Medical UniversityDepartment of Emergency Medicine, Department of Emergency and Critical Care Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical SciencesDepartment of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Gastroenterology, the First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityDepartment of Gastroenterology, the First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Gastroenterology, Nanfang Hospital of Southern Medical University, Guangdong Provincial Key Laboratory of GastroenterologyDepartment of Gastroenterology, the First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of General Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, The Second School of Clinical Medicine, Southern Medical UniversityAbstract Background This study aimed to develop a nomogram that predicts the overall survival (OS) of rectal neuroendocrine tumours (NETs). Methods We retrospectively analysed 310 patients with rectal neuroendocrine tumours in 5 hospitals in southern China. All of the patients were assigned to the training set. A multivariable analysis using Cox proportional hazards regression was performed using the training set, and a nomogram was constructed. It was validated on a dataset obtained from the Surveillance, Epidemiology, and End Result (SEER) database of America (n = 547). Results In the training set, the nomogram exhibited improved discrimination power compared with the WHO grade guidelines (Herrell’s C-index, 0.872 vs 0.794; p < 0.001) and was also better than the seventh AJCC TNM classification (Herrell’s C-index, 0.872 vs 0.817; p < 0.001). In the SEER validation dataset, the discrimination was also excellent (C-index, 0.648 vs 0.583, p < 0.001 and 0.648 vs 0.603, p = 0.016, respectively, compared with G grade and TNM classification). Calibration of the nomogram predicted individual survival corresponding closely with the actual survival. Conclusions We developed a nomogram predicting 1- and 3-year OS of patients with rectal neuroendocrine tumours. Validation revealed excellent discrimination and calibration, suggesting good clinical utility.http://link.springer.com/article/10.1186/s12885-020-07328-9Rectal neoplasmsNeuroendocrine tumoursNomogramOverall survival |
| spellingShingle | Xingyu Feng Gengzhou Wei Wei Wang Yu Zhang Yujie Zeng Minhu Chen Ye Chen Jie Chen Zhiwei Zhou Yong Li Nomogram for individually predicting overall survival in rectal neuroendocrine tumours BMC Cancer Rectal neoplasms Neuroendocrine tumours Nomogram Overall survival |
| title | Nomogram for individually predicting overall survival in rectal neuroendocrine tumours |
| title_full | Nomogram for individually predicting overall survival in rectal neuroendocrine tumours |
| title_fullStr | Nomogram for individually predicting overall survival in rectal neuroendocrine tumours |
| title_full_unstemmed | Nomogram for individually predicting overall survival in rectal neuroendocrine tumours |
| title_short | Nomogram for individually predicting overall survival in rectal neuroendocrine tumours |
| title_sort | nomogram for individually predicting overall survival in rectal neuroendocrine tumours |
| topic | Rectal neoplasms Neuroendocrine tumours Nomogram Overall survival |
| url | http://link.springer.com/article/10.1186/s12885-020-07328-9 |
| work_keys_str_mv | AT xingyufeng nomogramforindividuallypredictingoverallsurvivalinrectalneuroendocrinetumours AT gengzhouwei nomogramforindividuallypredictingoverallsurvivalinrectalneuroendocrinetumours AT weiwang nomogramforindividuallypredictingoverallsurvivalinrectalneuroendocrinetumours AT yuzhang nomogramforindividuallypredictingoverallsurvivalinrectalneuroendocrinetumours AT yujiezeng nomogramforindividuallypredictingoverallsurvivalinrectalneuroendocrinetumours AT minhuchen nomogramforindividuallypredictingoverallsurvivalinrectalneuroendocrinetumours AT yechen nomogramforindividuallypredictingoverallsurvivalinrectalneuroendocrinetumours AT jiechen nomogramforindividuallypredictingoverallsurvivalinrectalneuroendocrinetumours AT zhiweizhou nomogramforindividuallypredictingoverallsurvivalinrectalneuroendocrinetumours AT yongli nomogramforindividuallypredictingoverallsurvivalinrectalneuroendocrinetumours |