Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications
Nanostructure bicontinuous cubic phase self-assembled materials are receiving expanding applications as biocompatible delivery systems in various therapeutic fields. The functionalization of cubosome, spongosome, hexosome and liposome nanocarriers by pH-sensitive lipids and/or pH-sensitive polymer s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/5/963 |
| _version_ | 1797567640117444608 |
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| author | Omar Mertins Patrick D. Mathews Angelina Angelova |
| author_facet | Omar Mertins Patrick D. Mathews Angelina Angelova |
| author_sort | Omar Mertins |
| collection | DOAJ |
| description | Nanostructure bicontinuous cubic phase self-assembled materials are receiving expanding applications as biocompatible delivery systems in various therapeutic fields. The functionalization of cubosome, spongosome, hexosome and liposome nanocarriers by pH-sensitive lipids and/or pH-sensitive polymer shells offers new opportunities for oral and topical drug delivery towards a new generation of cancer therapies. The electrochemical behavior of drug compounds may favor pH-triggered drug release as well. Here, we highlight recent investigations, which explore the phase behavior of mixed nonlamellar lipid/fatty acid or phospholipid systems for the design of pH-responsive and mucoadhesive drug delivery systems with sustained-release properties. X-ray diffraction and small-angle X-ray scattering (SAXS) techniques are widely used in the development of innovative delivery assemblies through detailed structural analyses of multiple amphiphilic compositions from the lipid/co-lipid/water phase diagrams. pH-responsive nanoscale materials and nanoparticles are required for challenging therapeutic applications such as oral delivery of therapeutic proteins and peptides as well as of poorly water-soluble substances. Perspective nanomedicine developments with smart cubosome nanocarriers may exploit compositions elaborated to overcome the intestinal obstacles, dual-drug loaded pH-sensitive liquid crystalline architectures aiming at enhanced therapeutic efficacy, as well as composite (lipid/polyelectrolyte) types of mucoadhesive controlled release colloidal cubosomal formulations for the improvement of the drugs’ bioavailability. |
| first_indexed | 2024-03-10T19:45:56Z |
| format | Article |
| id | doaj.art-a0a265c383d3456988911bf55c11ccbe |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T19:45:56Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-a0a265c383d3456988911bf55c11ccbe2023-11-20T00:52:08ZengMDPI AGNanomaterials2079-49912020-05-0110596310.3390/nano10050963Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery ApplicationsOmar Mertins0Patrick D. Mathews1Angelina Angelova2Institut Galien Paris-Saclay UMR8612, Université Paris-Saclay, CNRS, F-92296 Châtenay-Malabry, FranceLaboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04023-062, BrazilInstitut Galien Paris-Saclay UMR8612, Université Paris-Saclay, CNRS, F-92296 Châtenay-Malabry, FranceNanostructure bicontinuous cubic phase self-assembled materials are receiving expanding applications as biocompatible delivery systems in various therapeutic fields. The functionalization of cubosome, spongosome, hexosome and liposome nanocarriers by pH-sensitive lipids and/or pH-sensitive polymer shells offers new opportunities for oral and topical drug delivery towards a new generation of cancer therapies. The electrochemical behavior of drug compounds may favor pH-triggered drug release as well. Here, we highlight recent investigations, which explore the phase behavior of mixed nonlamellar lipid/fatty acid or phospholipid systems for the design of pH-responsive and mucoadhesive drug delivery systems with sustained-release properties. X-ray diffraction and small-angle X-ray scattering (SAXS) techniques are widely used in the development of innovative delivery assemblies through detailed structural analyses of multiple amphiphilic compositions from the lipid/co-lipid/water phase diagrams. pH-responsive nanoscale materials and nanoparticles are required for challenging therapeutic applications such as oral delivery of therapeutic proteins and peptides as well as of poorly water-soluble substances. Perspective nanomedicine developments with smart cubosome nanocarriers may exploit compositions elaborated to overcome the intestinal obstacles, dual-drug loaded pH-sensitive liquid crystalline architectures aiming at enhanced therapeutic efficacy, as well as composite (lipid/polyelectrolyte) types of mucoadhesive controlled release colloidal cubosomal formulations for the improvement of the drugs’ bioavailability.https://www.mdpi.com/2079-4991/10/5/963pH-sensitive mesophase lipid structurescubosomes with pH-responsive polymer shellsself-assembled lyotropic liquid crystalline nanoparticlesnonlamellar lipidsphase transitionsdrug delivery vehicles |
| spellingShingle | Omar Mertins Patrick D. Mathews Angelina Angelova Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications Nanomaterials pH-sensitive mesophase lipid structures cubosomes with pH-responsive polymer shells self-assembled lyotropic liquid crystalline nanoparticles nonlamellar lipids phase transitions drug delivery vehicles |
| title | Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications |
| title_full | Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications |
| title_fullStr | Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications |
| title_full_unstemmed | Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications |
| title_short | Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications |
| title_sort | advances in the design of ph sensitive cubosome liquid crystalline nanocarriers for drug delivery applications |
| topic | pH-sensitive mesophase lipid structures cubosomes with pH-responsive polymer shells self-assembled lyotropic liquid crystalline nanoparticles nonlamellar lipids phase transitions drug delivery vehicles |
| url | https://www.mdpi.com/2079-4991/10/5/963 |
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