Epitranscriptomics: A New Layer of microRNA Regulation in Cancer
MicroRNAs are pervasive regulators of gene expression at the post-transcriptional level in metazoan, playing key roles in several physiological and pathological processes. Accordingly, these small non-coding RNAs are also involved in cancer development and progression. Furthermore, miRNAs represent...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/13/3372 |
| _version_ | 1797528082792316928 |
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| author | Veronica De Paolis Elisa Lorefice Elisa Orecchini Claudia Carissimi Ilaria Laudadio Valerio Fulci |
| author_facet | Veronica De Paolis Elisa Lorefice Elisa Orecchini Claudia Carissimi Ilaria Laudadio Valerio Fulci |
| author_sort | Veronica De Paolis |
| collection | DOAJ |
| description | MicroRNAs are pervasive regulators of gene expression at the post-transcriptional level in metazoan, playing key roles in several physiological and pathological processes. Accordingly, these small non-coding RNAs are also involved in cancer development and progression. Furthermore, miRNAs represent valuable diagnostic and prognostic biomarkers in malignancies. In the last twenty years, the role of RNA modifications in fine-tuning gene expressions at several levels has been unraveled. All RNA species may undergo post-transcriptional modifications, collectively referred to as epitranscriptomic modifications, which, in many instances, affect RNA molecule properties. miRNAs are not an exception, in this respect, and they have been shown to undergo several post-transcriptional modifications. In this review, we will summarize the recent findings concerning miRNA epitranscriptomic modifications, focusing on their potential role in cancer development and progression. |
| first_indexed | 2024-03-10T09:53:03Z |
| format | Article |
| id | doaj.art-a0a392d99a21488f896a7c59d009331f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:53:03Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a0a392d99a21488f896a7c59d009331f2023-11-22T02:36:49ZengMDPI AGCancers2072-66942021-07-011313337210.3390/cancers13133372Epitranscriptomics: A New Layer of microRNA Regulation in CancerVeronica De Paolis0Elisa Lorefice1Elisa Orecchini2Claudia Carissimi3Ilaria Laudadio4Valerio Fulci5Dipartimento di Medicina Molecolare, Sapienza Università di Roma, 00161 Rome, ItalyDipartimento di Medicina Molecolare, Sapienza Università di Roma, 00161 Rome, ItalyDipartimento di Medicina Molecolare, Sapienza Università di Roma, 00161 Rome, ItalyDipartimento di Medicina Molecolare, Sapienza Università di Roma, 00161 Rome, ItalyDipartimento di Medicina Molecolare, Sapienza Università di Roma, 00161 Rome, ItalyDipartimento di Medicina Molecolare, Sapienza Università di Roma, 00161 Rome, ItalyMicroRNAs are pervasive regulators of gene expression at the post-transcriptional level in metazoan, playing key roles in several physiological and pathological processes. Accordingly, these small non-coding RNAs are also involved in cancer development and progression. Furthermore, miRNAs represent valuable diagnostic and prognostic biomarkers in malignancies. In the last twenty years, the role of RNA modifications in fine-tuning gene expressions at several levels has been unraveled. All RNA species may undergo post-transcriptional modifications, collectively referred to as epitranscriptomic modifications, which, in many instances, affect RNA molecule properties. miRNAs are not an exception, in this respect, and they have been shown to undergo several post-transcriptional modifications. In this review, we will summarize the recent findings concerning miRNA epitranscriptomic modifications, focusing on their potential role in cancer development and progression.https://www.mdpi.com/2072-6694/13/13/3372microRNAcancerepitranscriptomicsm6Am5CA-to-I editing |
| spellingShingle | Veronica De Paolis Elisa Lorefice Elisa Orecchini Claudia Carissimi Ilaria Laudadio Valerio Fulci Epitranscriptomics: A New Layer of microRNA Regulation in Cancer Cancers microRNA cancer epitranscriptomics m6A m5C A-to-I editing |
| title | Epitranscriptomics: A New Layer of microRNA Regulation in Cancer |
| title_full | Epitranscriptomics: A New Layer of microRNA Regulation in Cancer |
| title_fullStr | Epitranscriptomics: A New Layer of microRNA Regulation in Cancer |
| title_full_unstemmed | Epitranscriptomics: A New Layer of microRNA Regulation in Cancer |
| title_short | Epitranscriptomics: A New Layer of microRNA Regulation in Cancer |
| title_sort | epitranscriptomics a new layer of microrna regulation in cancer |
| topic | microRNA cancer epitranscriptomics m6A m5C A-to-I editing |
| url | https://www.mdpi.com/2072-6694/13/13/3372 |
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