Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier
The aim of the current study was to fabricate naturally derived polymer based hydrogels for controlled release of diclofenac sodium (DS) for a long duration of time. In this research work, sodium alginate-co-poly(2-acrylamido-2-methyl propane sulphonic acid) (SA-co-poly(AMPS)) hydrogels were prepare...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/2310-2861/7/1/10 |
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| author | Muhammad Suhail Arshad Khan Jessica M Rosenholm Muhammad Usman Minhas Pao-Chu Wu |
| author_facet | Muhammad Suhail Arshad Khan Jessica M Rosenholm Muhammad Usman Minhas Pao-Chu Wu |
| author_sort | Muhammad Suhail |
| collection | DOAJ |
| description | The aim of the current study was to fabricate naturally derived polymer based hydrogels for controlled release of diclofenac sodium (DS) for a long duration of time. In this research work, sodium alginate-co-poly(2-acrylamido-2-methyl propane sulphonic acid) (SA-co-poly(AMPS)) hydrogels were prepared by the free radical polymerization technique, where sodium alginate (SA) and 2-acrylamido-2-methyl propane sulphonic acid (AMPS) were used as the polymer and monomer while ammonium peroxodisulfate (APS) and N,N′-Methylene bisacrylamide (MBA) were used as the initiator and cross-linker, respectively. A swelling study was performed to determine the swelling index of developed hydrogels in both acidic (pH 1.2) and basic (pH 7.4) media and pH-independent swelling was observed due to the presence of AMPS. An in vitro release study was conducted to evaluate the percentage of drug released, and a high release of the drug was found at the higher pH of 7.4. Sol–gel analysis was performed to analyze the crosslinked and uncrosslinked part of the hydrogels, and results showed a rise in gel fraction as the composition of SA, AMPS and MBA increased while the sol fraction decreased and vice versa. This work demonstrated a potential for sustained delivery of diclofenac sodium by employing various concentration of SA, AMPS and MBA. |
| first_indexed | 2024-03-09T03:30:42Z |
| format | Article |
| id | doaj.art-a0a3d2f7ffa14170b3ce6b803241b41e |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T03:30:42Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-a0a3d2f7ffa14170b3ce6b803241b41e2023-12-03T14:56:52ZengMDPI AGGels2310-28612021-01-01711010.3390/gels7010010Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release CarrierMuhammad Suhail0Arshad Khan1Jessica M Rosenholm2Muhammad Usman Minhas3Pao-Chu Wu4School of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung City 80708, TaiwanDepartment of Pharmaceutics, Faculty of Pharmacy, Khawaja Fareed Campus (Railway Road), The Islamia University of Bahawalpur, Punjab 63100, PakistanPharmaceutical Sciences Laboratory, Faculty of Science & Engineering, Åbo Akademi University, BioCity (3rd floor), Tykistökatu 6A, 20520 Turku, FinlandCollege of Pharmacy, University of Sargodha, Sargodha 40100, PakistanDepartment of Medical Research, School of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung 80708, TaiwanThe aim of the current study was to fabricate naturally derived polymer based hydrogels for controlled release of diclofenac sodium (DS) for a long duration of time. In this research work, sodium alginate-co-poly(2-acrylamido-2-methyl propane sulphonic acid) (SA-co-poly(AMPS)) hydrogels were prepared by the free radical polymerization technique, where sodium alginate (SA) and 2-acrylamido-2-methyl propane sulphonic acid (AMPS) were used as the polymer and monomer while ammonium peroxodisulfate (APS) and N,N′-Methylene bisacrylamide (MBA) were used as the initiator and cross-linker, respectively. A swelling study was performed to determine the swelling index of developed hydrogels in both acidic (pH 1.2) and basic (pH 7.4) media and pH-independent swelling was observed due to the presence of AMPS. An in vitro release study was conducted to evaluate the percentage of drug released, and a high release of the drug was found at the higher pH of 7.4. Sol–gel analysis was performed to analyze the crosslinked and uncrosslinked part of the hydrogels, and results showed a rise in gel fraction as the composition of SA, AMPS and MBA increased while the sol fraction decreased and vice versa. This work demonstrated a potential for sustained delivery of diclofenac sodium by employing various concentration of SA, AMPS and MBA.https://www.mdpi.com/2310-2861/7/1/10hydrogelssodium alginatein-vitro studydissolutionkinetic modeling |
| spellingShingle | Muhammad Suhail Arshad Khan Jessica M Rosenholm Muhammad Usman Minhas Pao-Chu Wu Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier Gels hydrogels sodium alginate in-vitro study dissolution kinetic modeling |
| title | Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier |
| title_full | Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier |
| title_fullStr | Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier |
| title_full_unstemmed | Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier |
| title_short | Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier |
| title_sort | fabrication and characterization of diclofenac sodium loaded hydrogels of sodium alginate as sustained release carrier |
| topic | hydrogels sodium alginate in-vitro study dissolution kinetic modeling |
| url | https://www.mdpi.com/2310-2861/7/1/10 |
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