Iron Metabolism as a Potential Mechanism for Inducing TRAIL-Mediated Extrinsic Apoptosis Using Methylsulfonylmethane in Embryonic Cancer Stem Cells

Iron Metabolism as a Potential Mechanism for Inducing TRAIL-Mediated Extrinsic Apoptosis Using Methylsulfonylmethane in Embryonic Cancer Stem Cells

Embryonic cancer stem cells (CSCs) can differentiate into any cancer type. Targeting CSC using natural compounds is a good approach as it suppresses cancer recurrence with fewer adverse effects, and methylsulfonylmethane (MSM) is a sulfur-containing compound with well-known anticancer activities. Th...

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Bibliographic Details
Main Authors: Nipin Sp, Dong Young Kang, Eun Seong Jo, Jin-Moo Lee, Kyoung-Jin Jang
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
NCCIT
NTERA-2
MSM
TRAIL
iron metabolism
p38/p53/ERK signaling
Online Access:https://www.mdpi.com/2073-4409/10/11/2847

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