A meta-analysis and real-world cohort study on the sex-related differences in efficacy and safety of immunotherapy for hepatocellular carcinoma

A meta-analysis and real-world cohort study on the sex-related differences in efficacy and safety of immunotherapy for hepatocellular carcinoma

Background & Aims: Sex-related differences in the immune pathogenesis of hepatocellular carcinoma (HCC), particularly related to oestrogen-dependent secretion of pro-tumourigenic cytokines, are well-known. Whether sex influences the efficacy and safety of immunotherapy is not known. Methods:...

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Main Authors: Lorenz Balcar, Bernhard Scheiner, Claudia Angela Maria Fulgenzi, Antonio D’Alessio, Katharina Pomej, Marta Bofill Roig, Elias Laurin Meyer, Jaekyung Che, Naoshi Nishida, Pei-Chang Lee, Linda Wu, Celina Ang, Anja Krall, Anwaar Saeed, Bernardo Stefanini, Antonella Cammarota, Tiziana Pressiani, Yehia I. Abugabal, Shadi Chamseddine, Brooke Wietharn, Alessandro Parisi, Yi-Hsiang Huang, Samuel Phen, Caterina Vivaldi, Francesca Salani, Gianluca Masi, Dominik Bettinger, Arndt Vogel, Johann von Felden, Kornelius Schulze, Marianna Silletta, Michael Trauner, Adel Samson, Henning Wege, Fabio Piscaglia, Peter R. Galle, Rudolf Stauber, Masatoshi Kudo, Amit G. Singal, Aleena Itani, Susanna V. Ulahannan, Neehar D. Parikh, Alessio Cortellini, Ahmed Kaseb, Lorenza Rimassa, Hong Jae Chon, David J. Pinato, Matthias Pinter
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:JHEP Reports
Subjects:
gender
liver cancer
gender medicine
immunotherapy
sex
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923003130

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