Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments. Craving for alcohol and its consequences depends, among other things, on the endocannabinoi...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Luis Santos-Molina, Alexa Herrerias, Charles N. Zawatsky, Ozge Gunduz-Cinar, Resat Cinar, Malliga R. Iyer, Casey M. Wood, Yuhong Lin, Bin Gao, George Kunos, Grzegorz Godlewski
स्वरूप:	लेख
भाषा:	English
प्रकाशित:	MDPI AG 2021-08-01
श्रृंखला:	Molecules
विषय:	cannabinoid MRI-1867 hybrid ligand CB1 receptor antagonist iNOS inhibitor rimonabant
ऑनलाइन पहुंच:	https://www.mdpi.com/1420-3049/26/16/5089

समान संसाधन

Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis
द्वारा: Charles N. Zawatsky, और अन्य
प्रकाशित: (2021-09-01)

Requiem for Rimonabant: Therapeutic Potential for Cannabinoid CB<sub>1</sub> Receptor Antagonists after the Fall
द्वारा: Taryn Bosquez-Berger, और अन्य
प्रकाशित: (2023-08-01)

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors
द्वारा: Adriano Mollica, और अन्य
प्रकाशित: (2017-01-01)

The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice
द्वारा: Francisco J. Bermudez-Silva, और अन्य
प्रकाशित: (2016-01-01)

The Cannabinoid CB1 Antagonist TM38837 With Limited Penetrance to the Brain Shows Reduced Fear-Promoting Effects in Mice
द्वारा: Vincenzo Micale, और अन्य
प्रकाशित: (2019-03-01)

The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
द्वारा: Mansour Haddad
प्रकाशित: (2021-10-01)

The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
द्वारा: Carlos Costas-Insua, और अन्य
प्रकाशित: (2024-03-01)

Neutral CB1 Receptor Antagonists as Pharmacotherapies for Substance Use Disorders: Rationale, Evidence, and Challenge
द्वारा: Omar Soler-Cedeno, और अन्य
प्रकाशित: (2022-10-01)

The CB1 cannabinoid receptor antagonist rimonabant chronically prevents the nicotine-induced relapse to alcohol
द्वारा: José Antonio López-Moreno, और अन्य
प्रकाशित: (2007-02-01)

Context-dependent effects of the CB1 receptor antagonist rimonabant on morphine-induced behavioral sensitization in female mice
द्वारा: Eduardo A. V. Marinho, और अन्य
प्रकाशित: (2023-02-01)

Inducible Nitric Oxide Synthase Inhibition in the Medial Prefrontal Cortex Attenuates the Anxiogenic-Like Effect of Acute Restraint Stress via CB1 Receptors
द्वारा: Arthur A. Coelho, और अन्य
प्रकाशित: (2022-07-01)

Maternal sevoflurane exposure induces neurotoxicity in offspring rats via the CB1R/CDK5/p-tau pathway
द्वारा: Yuxiao Wan, और अन्य
प्रकाशित: (2023-01-01)

Depression-like phenotype following chronic CB1 receptor antagonism
द्वारा: Chad E. Beyer, और अन्य
प्रकाशित: (2010-08-01)

iNOS is associated with tumorigenicity as an independent prognosticator in human intrahepatic cholangiocarcinoma
द्वारा: Liu S, और अन्य
प्रकाशित: (2019-08-01)

The role of cannabinoid receptor 1 in the development of oxidative/nitrosative stress in mice with non-alcoholic fatty liver disease
द्वारा: Brkić Dušan, और अन्य
प्रकाशित: (2019-01-01)

Targeting the Endocannabinoid/CB1 Receptor System For Treating Major Depression Through Antidepressant Activities of Curcumin and Dexanabinol-Loaded Solid Lipid Nanoparticles
द्वारा: Xiaolie He, और अन्य
प्रकाशित: (2017-08-01)

iNOS expressing macrophages co-localize with nitrotyrosine staining after myocardial infarction in humans
द्वारा: Verena Wilmes, और अन्य
प्रकाशित: (2023-03-01)

iNOS polymorphism modulates iNOS/NO expression via impaired antioxidant and ROS content in P. vivax and P. falciparum infection
द्वारा: Amod Kumar, और अन्य
प्रकाशित: (2018-05-01)

Upregulation of iNOS and phosphorylated eNOS in the implantation‐induced blastocysts of mice
द्वारा: Misato Seki, और अन्य
प्रकाशित: (2023-01-01)

Cuantificación de células endoteliales que expresan VEGF, iNOS y eNOS en el endometrio ovino a los 20, 28 y 35 días de la gestación Quantification of endothelial cells expressing VEGF, iNOS and eNOS in the ovine endometrium at 20, 28 and 35 days of gestation
द्वारा: Piedad C Rivas, और अन्य
प्रकाशित: (2007-09-01)

Neuroimmunomodulation in Chronic Wound Healing after Treatment with Photodynamic Therapy: The Role of iNOs
द्वारा: Lorenzo Notari, और अन्य
प्रकाशित: (2023-03-01)

Myosin V and iNOS expression is enhanced in J774 murine macrophages treated with IFN-gamma
द्वारा: D.S. Reis, और अन्य
प्रकाशित: (2001-02-01)

Therapeutic effects of iNOS inhibition against vitiligo in an animal model
द्वारा: Hamid Mansourpour, और अन्य
प्रकाशित: (2019-08-01)

Targeting iNOS to increase efficacy of immunotherapies
द्वारा: Suhendan Ekmekcioglu, और अन्य
प्रकाशित: (2017-05-01)

Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects
द्वारा: Jason Sadek, और अन्य
प्रकाशित: (2021-06-01)

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence
द्वारा: Mikkel Søes Ibsen, और अन्य
प्रकाशित: (2019-04-01)

Role of iNOS and eNOS expression in a group of Egyptian diabetic and nondiabetic nephropathy patients
द्वारा: Mayssa I. Aly, और अन्य
प्रकाशित: (2013-01-01)

iNOS Deletion in Alveolar Epithelium Cannot Reverse the Elastase-Induced Emphysema in Mice
द्वारा: Marija Gredic, और अन्य
प्रकाशित: (2022-12-01)

iNOS Induces Vascular Endothelial Cell Migration and Apoptosis Via Autophagy in Ischemia/Reperfusion Injury
द्वारा: Tiebing Zhu, और अन्य
प्रकाशित: (2016-04-01)

Effects of Contamination Detergent (Las) On The Expression Of iNOS In Kidney Common Carp (Cyprinus carpio L.)
द्वारा: Ruku R. Borut
प्रकाशित: (2014-01-01)

Effect of aminoguanidine and albendazole on inducible nitric oxide synthase (iNOS) activity in <i>T. spiralis</i>-infected mice muscles
द्वारा: Iwona Mozer-Lisewska, और अन्य
प्रकाशित: (2011-08-01)

An enquiry to the role of CB1 receptors in neurodegeneration
द्वारा: Ignacio Fernández-Moncada, और अन्य
प्रकाशित: (2023-08-01)

Obesity, inflammation, and exercise training: relative contribution of iNOS and eNOS in the modulation of vascular function in the mouse aorta
द्वारा: Josiane Fernandes da Silva, और अन्य
प्रकाशित: (2016-09-01)

Nitric oxide promotes differentiation of rat white preadipocytes in culture
द्वारा: Hongyun Yan, और अन्य
प्रकाशित: (2002-12-01)

Aging alters the production of iNOS, arginase and cytokines in murine macrophages
द्वारा: C.A. Cecílio, और अन्य
प्रकाशित: (2011-07-01)

Human umbilical cord expresses several vasoactive peptides involved in the local regulation of vascular tone: protein and gene expression of Orphanin, Oxytocin, ANP, eNOS and iNOS
द्वारा: Aldo Gerbino, और अन्य
प्रकाशित: (2011-07-01)

iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation
द्वारा: Yongzheng Guo, और अन्य
प्रकाशित: (2023-01-01)

Quercetin modulates iNOS, eNOS and NOSTRIN expressions and attenuates oxidative stress in warm hepatic ischemia-reperfusion injury in rats
द्वारा: Mohamed Abd-Elbaset, और अन्य
प्रकाशित: (2015-09-01)

2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia
द्वारा: Susan F. Fitzpatrick, और अन्य
प्रकाशित: (2020-03-01)

Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure
द्वारा: Sally Miller, और अन्य
प्रकाशित: (2018-05-01)