Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments. Craving for alcohol and its consequences depends, among other things, on the endocannabinoi...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Luis Santos-Molina, Alexa Herrerias, Charles N. Zawatsky, Ozge Gunduz-Cinar, Resat Cinar, Malliga R. Iyer, Casey M. Wood, Yuhong Lin, Bin Gao, George Kunos, Grzegorz Godlewski
Формат:	Өгүүллэг
Хэл сонгох:	English
Хэвлэсэн:	MDPI AG 2021-08-01
Цуврал:	Molecules
Нөхцлүүд:	cannabinoid MRI-1867 hybrid ligand CB1 receptor antagonist iNOS inhibitor rimonabant
Онлайн хандалт:	https://www.mdpi.com/1420-3049/26/16/5089

Ижил төстэй зүйлс

Requiem for Rimonabant: Therapeutic Potential for Cannabinoid CB<sub>1</sub> Receptor Antagonists after the Fall
-н: Taryn Bosquez-Berger, зэрэг
Хэвлэсэн: (2023-08-01)

The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
-н: Mansour Haddad
Хэвлэсэн: (2021-10-01)

The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
-н: Carlos Costas-Insua, зэрэг
Хэвлэсэн: (2024-03-01)

Neutral CB1 Receptor Antagonists as Pharmacotherapies for Substance Use Disorders: Rationale, Evidence, and Challenge
-н: Omar Soler-Cedeno, зэрэг
Хэвлэсэн: (2022-10-01)

Upregulation of iNOS and phosphorylated eNOS in the implantation‐induced blastocysts of mice
-н: Misato Seki, зэрэг
Хэвлэсэн: (2023-01-01)

Neuroimmunomodulation in Chronic Wound Healing after Treatment with Photodynamic Therapy: The Role of iNOs
-н: Lorenzo Notari, зэрэг
Хэвлэсэн: (2023-03-01)

Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects
-н: Jason Sadek, зэрэг
Хэвлэсэн: (2021-06-01)

Targeting iNOS to increase efficacy of immunotherapies
-н: Suhendan Ekmekcioglu, зэрэг
Хэвлэсэн: (2017-05-01)

iNOS Deletion in Alveolar Epithelium Cannot Reverse the Elastase-Induced Emphysema in Mice
-н: Marija Gredic, зэрэг
Хэвлэсэн: (2022-12-01)

Turmeric Extract (<i>Curcuma longa</i>) Mediates Anti-Oxidative Effects by Reduction of Nitric Oxide, iNOS Protein-, and mRNA-Synthesis in BV2 Microglial Cells
-н: Jana Streyczek, зэрэг
Хэвлэсэн: (2022-01-01)

Paneth cell-derived iNOS is required to maintain homeostasis in the intestinal stem cell niche
-н: Lingxiao Huang, зэрэг
Хэвлэсэн: (2023-11-01)

Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Rat and Human Spinal Cord
-н: Jessica Parnell, зэрэг
Хэвлэсэн: (2023-07-01)

Propofol protects against high glucose-mediated endothelial injury via inhibition of COX2 and iNOS expressions
-н: Shao Jiayun, зэрэг
Хэвлэсэн: (2022-03-01)

The Breast Cancer Protooncogenes HER2, BRCA1 and BRCA2 and Their Regulation by the iNOS/NOS2 Axis
-н: Katie Lin, зэрэг
Хэвлэсэн: (2022-06-01)

Value of alpha smooth muscle actin (αSMA) and inducible nitric oxide synthase (iNOS) in oral squamous cell carcinoma (OSCC): An immunohistochemical approach to tumor stroma categorization and clinicopathological parameters
-н: Heba E.M. Youssef, зэрэг
Хэвлэсэн: (2025-03-01)

Monitoring the immune response of macrophages in tuberculous granuloma through the expression of CD68, iNOS and HLA-DR in naturally infected beef cattle
-н: Mohamed G. Hamed, зэрэг
Хэвлэсэн: (2023-10-01)

Mild Hyperthermia Accelerates Bone Repair by Dynamically Regulating iNOS/Arg1 Balance in the Early Stage
-н: Jinhui Zhao, зэрэг
Хэвлэсэн: (2025-02-01)

Reduced Retinal Degeneration in an Oxidative Stress Organ Culture Model through an iNOS-Inhibitor
-н: Ana M. Mueller-Buehl, зэрэг
Хэвлэсэн: (2021-04-01)

Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO
-н: Khosrow Kashfi, зэрэг
Хэвлэсэн: (2021-11-01)

iNOS-Produced Nitric Oxide from Cancer Cells as an Intermediate of Stemness Regulation by PARP-1 in Colorectal Cancer
-н: María del Moral-Martinez, зэрэг
Хэвлэсэн: (2025-01-01)

Blends of Organic Acids Are Weaponizing the Host iNOS and Nitric Oxide to Reduce Infection of <i>Piscirickettsia salmonis</i> in vitro
-н: Nicolae Corcionivoschi, зэрэг
Хэвлэсэн: (2024-04-01)

Gut cannabinoid receptor 1 regulates alcohol binge-induced intestinal permeability
-н: Bin Gao, зэрэг
Хэвлэсэн: (2025-02-01)

Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia
-н: Joanna M Wierońska, зэрэг
Хэвлэсэн: (2021-07-01)

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB2 receptor
-н: Monica Patel, зэрэг
Хэвлэсэн: (2023-12-01)

Brown garlic: A nutritionally improved garlic with therapeutic value in asthma treatment via modulation of S-nitrosothiols
-н: Geun-Mo Lee, зэрэг
Хэвлэсэн: (2024-09-01)

Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential
-н: Reem Smoum, зэрэг
Хэвлэсэн: (2022-02-01)

7-Hydroxy Frullanolide Ameliorates Isoproterenol-Induced Myocardial Injury through Modification of iNOS and Nrf2 Genes
-н: Saif Ullah, зэрэг
Хэвлэсэн: (2023-09-01)

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting
-н: Derek T Hall, зэрэг
Хэвлэсэн: (2018-05-01)

In silico and in vivo evaluation of the anti-cryptosporidial activity of eugenol
-н: Hattan S. Gattan, зэрэг
Хэвлэсэн: (2024-03-01)

Corrigendum: In silico and in vivo evaluation of the anti-cryptosporidial activity of eugenol
-н: Hattan S. Gattan, зэрэг
Хэвлэсэн: (2024-05-01)

IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children
-н: Myung Woul Han, зэрэг
Хэвлэсэн: (2024-01-01)

Cytokine-Induced iNOS in A549 Alveolar Epithelial Cells: A Potential Role in COVID-19 Lung Pathology
-н: Amelia Barilli, зэрэг
Хэвлэсэн: (2023-10-01)

Influence of rimonabant treatment on peripheral blood mononuclear cells; flow cytometry analysis and gene expression profiling
-н: Stefan Almestrand, зэрэг
Хэвлэсэн: (2015-06-01)

Acetamidine-Based iNOS Inhibitors as Molecular Tools to Counteract Inflammation in BV2 Microglial Cells
-н: Silvia Grottelli, зэрэг
Хэвлэсэн: (2020-06-01)

Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells
-н: Francesca Gado, зэрэг
Хэвлэсэн: (2022-05-01)

Transient Expression of Reck Under Hepatic Ischemia/Reperfusion Conditions Is Associated with Mapk Signaling Pathways
-н: Andrea Ferrigno, зэрэг
Хэвлэсэн: (2020-05-01)

A Critical Evaluation of Terpenoid Signaling at Cannabinoid CB1 Receptors in a Neuronal Model
-н: Michaela Dvorakova, зэрэг
Хэвлэсэн: (2022-09-01)

Upregulation of ICAM-1 Expression on J774.2 Macrophages by Endotoxin Involves Activation of NF-κB but not Protein Tyrosine Kinase: Comparison to Induction of iNOS
-н: Hartmut Ruetten, зэрэг
Хэвлэсэн: (1999-01-01)

Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling
-н: Jakub Jakowiecki, зэрэг
Хэвлэсэн: (2021-04-01)

Cannabinoids and the endocannabinoid system in liver diseases
-н: Anna Parfieniuk-Kowerda, зэрэг
Хэвлэсэн: (2024-12-01)