Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments. Craving for alcohol and its consequences depends, among other things, on the endocannabinoi...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Luis Santos-Molina, Alexa Herrerias, Charles N. Zawatsky, Ozge Gunduz-Cinar, Resat Cinar, Malliga R. Iyer, Casey M. Wood, Yuhong Lin, Bin Gao, George Kunos, Grzegorz Godlewski
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2021-08-01
Schriftenreihe:Molecules
Schlagworte:
cannabinoid
MRI-1867
hybrid ligand
CB1 receptor antagonist
iNOS inhibitor
rimonabant
Online Zugang:https://www.mdpi.com/1420-3049/26/16/5089

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