A human multi-lineage hepatic organoid model for liver fibrosis
Autosomal recessive polycystic kidney disease (ARPKD) is a genetic disorder which is associated with kidney and liver pathology, including liver fibrosis. Here the authors develop and characterize human liver organoids with a ARPKD mutation, and find that they show aspects of the pathology, includin...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26410-9 |
| _version_ | 1819045068881788928 |
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| author | Yuan Guan Annika Enejder Meiyue Wang Zhuoqing Fang Lu Cui Shih-Yu Chen Jingxiao Wang Yalun Tan Manhong Wu Xinyu Chen Patrik K. Johansson Issra Osman Koshi Kunimoto Pierre Russo Sarah C. Heilshorn Gary Peltz |
| author_facet | Yuan Guan Annika Enejder Meiyue Wang Zhuoqing Fang Lu Cui Shih-Yu Chen Jingxiao Wang Yalun Tan Manhong Wu Xinyu Chen Patrik K. Johansson Issra Osman Koshi Kunimoto Pierre Russo Sarah C. Heilshorn Gary Peltz |
| author_sort | Yuan Guan |
| collection | DOAJ |
| description | Autosomal recessive polycystic kidney disease (ARPKD) is a genetic disorder which is associated with kidney and liver pathology, including liver fibrosis. Here the authors develop and characterize human liver organoids with a ARPKD mutation, and find that they show aspects of the pathology, including fibrosis. |
| first_indexed | 2024-12-21T10:22:42Z |
| format | Article |
| id | doaj.art-a0a7c814994743da9ab4dcaf12e47001 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T10:22:42Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a0a7c814994743da9ab4dcaf12e470012022-12-21T19:07:24ZengNature PortfolioNature Communications2041-17232021-10-0112111510.1038/s41467-021-26410-9A human multi-lineage hepatic organoid model for liver fibrosisYuan Guan0Annika Enejder1Meiyue Wang2Zhuoqing Fang3Lu Cui4Shih-Yu Chen5Jingxiao Wang6Yalun Tan7Manhong Wu8Xinyu Chen9Patrik K. Johansson10Issra Osman11Koshi Kunimoto12Pierre Russo13Sarah C. Heilshorn14Gary Peltz15Department of Anesthesiology, Pain and Perioperative MedicineDepartment of Materials Science and Engineering, Stanford UniversityDepartment of Anesthesiology, Pain and Perioperative MedicineDepartment of Anesthesiology, Pain and Perioperative MedicineDepartment of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of MedicineShih-Yu Chen, Institute of Biomedical Sciences, Academia SinicaDepartment of Anesthesiology, Pain and Perioperative MedicineDepartment of Anesthesiology, Pain and Perioperative MedicineDepartment of Anesthesiology, Pain and Perioperative MedicineDepartment of Anesthesiology, Pain and Perioperative MedicineDepartment of Materials Science and Engineering, Stanford UniversityDepartment of Anesthesiology, Pain and Perioperative MedicineDepartment of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of MedicinePerelman School of Medicine at The University of PennsylvaniaDepartment of Materials Science and Engineering, Stanford UniversityDepartment of Anesthesiology, Pain and Perioperative MedicineAutosomal recessive polycystic kidney disease (ARPKD) is a genetic disorder which is associated with kidney and liver pathology, including liver fibrosis. Here the authors develop and characterize human liver organoids with a ARPKD mutation, and find that they show aspects of the pathology, including fibrosis.https://doi.org/10.1038/s41467-021-26410-9 |
| spellingShingle | Yuan Guan Annika Enejder Meiyue Wang Zhuoqing Fang Lu Cui Shih-Yu Chen Jingxiao Wang Yalun Tan Manhong Wu Xinyu Chen Patrik K. Johansson Issra Osman Koshi Kunimoto Pierre Russo Sarah C. Heilshorn Gary Peltz A human multi-lineage hepatic organoid model for liver fibrosis Nature Communications |
| title | A human multi-lineage hepatic organoid model for liver fibrosis |
| title_full | A human multi-lineage hepatic organoid model for liver fibrosis |
| title_fullStr | A human multi-lineage hepatic organoid model for liver fibrosis |
| title_full_unstemmed | A human multi-lineage hepatic organoid model for liver fibrosis |
| title_short | A human multi-lineage hepatic organoid model for liver fibrosis |
| title_sort | human multi lineage hepatic organoid model for liver fibrosis |
| url | https://doi.org/10.1038/s41467-021-26410-9 |
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