Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study
Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
|
| Series: | Experimental Gerontology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556523001456 |
| _version_ | 1797736700864102400 |
|---|---|
| author | J. López-Herreros M.A. Martínez-González A. Gea A. Sánchez-Villegas T. Dierssen-Sotos J.J. Jiménez-Moleón M. Ruiz-Canela E. Toledo |
| author_facet | J. López-Herreros M.A. Martínez-González A. Gea A. Sánchez-Villegas T. Dierssen-Sotos J.J. Jiménez-Moleón M. Ruiz-Canela E. Toledo |
| author_sort | J. López-Herreros |
| collection | DOAJ |
| description | Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet. |
| first_indexed | 2024-03-12T13:16:42Z |
| format | Article |
| id | doaj.art-a0a83bb6ec1f45909eaa27d635cf2046 |
| institution | Directory Open Access Journal |
| issn | 1873-6815 |
| language | English |
| last_indexed | 2024-03-12T13:16:42Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj.art-a0a83bb6ec1f45909eaa27d635cf20462023-08-27T04:27:01ZengElsevierExperimental Gerontology1873-68152023-07-01178112224Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort studyJ. López-Herreros0M.A. Martínez-González1A. Gea2A. Sánchez-Villegas3T. Dierssen-Sotos4J.J. Jiménez-Moleón5M. Ruiz-Canela6E. Toledo7Universidad de Navarra, Department of Preventive Medicine and Public Health, Pamplona, SpainUniversidad de Navarra, Department of Preventive Medicine and Public Health, Pamplona, Spain; Biomedical Research Network Centre for Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; Department of Nutrition, Harvard T. H Chan School, Boston, MA 02115, USAUniversidad de Navarra, Department of Preventive Medicine and Public Health, Pamplona, Spain; Biomedical Research Network Centre for Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, SpainBiomedical Research Network Centre for Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; ISFOOD - Institute for Innovation & Sustainable Development in Food Chain, Universidad Pública de Navarra (UPNA), Pamplona, SpainBiomedical Research Network Centre for Pathophysiology of Epidemiology and Public Health (CIBERESP), Carlos III Health Institute, Madrid, Spain; IDIVAL Santander, 39011 Santander, Spain; Faculty of Medicine, University of Cantabria, 39011 Santander, SpainBiomedical Research Network Centre for Pathophysiology of Epidemiology and Public Health (CIBERESP), Carlos III Health Institute, Madrid, Spain; Universidad de Granada, Department of Preventive Medicine and Public Health, Granada, Spain; Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, SpainUniversidad de Navarra, Department of Preventive Medicine and Public Health, Pamplona, Spain; Biomedical Research Network Centre for Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, SpainUniversidad de Navarra, Department of Preventive Medicine and Public Health, Pamplona, Spain; Biomedical Research Network Centre for Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; Corresponding author at: Department of Preventive Medicine and Public Health, University of Navarra, Calle Irunlarrea, 1, 31008 Pamplona, Navarra, Spain.Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet.http://www.sciencedirect.com/science/article/pii/S0531556523001456Health-related quality of lifeMortalitySF-36CohortSUN project |
| spellingShingle | J. López-Herreros M.A. Martínez-González A. Gea A. Sánchez-Villegas T. Dierssen-Sotos J.J. Jiménez-Moleón M. Ruiz-Canela E. Toledo Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study Experimental Gerontology Health-related quality of life Mortality SF-36 Cohort SUN project |
| title | Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study |
| title_full | Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study |
| title_fullStr | Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study |
| title_full_unstemmed | Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study |
| title_short | Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study |
| title_sort | health related quality of life and mortality in the seguimiento universidad de navarra prospective cohort study |
| topic | Health-related quality of life Mortality SF-36 Cohort SUN project |
| url | http://www.sciencedirect.com/science/article/pii/S0531556523001456 |
| work_keys_str_mv | AT jlopezherreros healthrelatedqualityoflifeandmortalityintheseguimientouniversidaddenavarraprospectivecohortstudy AT mamartinezgonzalez healthrelatedqualityoflifeandmortalityintheseguimientouniversidaddenavarraprospectivecohortstudy AT agea healthrelatedqualityoflifeandmortalityintheseguimientouniversidaddenavarraprospectivecohortstudy AT asanchezvillegas healthrelatedqualityoflifeandmortalityintheseguimientouniversidaddenavarraprospectivecohortstudy AT tdierssensotos healthrelatedqualityoflifeandmortalityintheseguimientouniversidaddenavarraprospectivecohortstudy AT jjjimenezmoleon healthrelatedqualityoflifeandmortalityintheseguimientouniversidaddenavarraprospectivecohortstudy AT mruizcanela healthrelatedqualityoflifeandmortalityintheseguimientouniversidaddenavarraprospectivecohortstudy AT etoledo healthrelatedqualityoflifeandmortalityintheseguimientouniversidaddenavarraprospectivecohortstudy |