Effects of Berberis vulgaris fractions on PTZ Induced seizure in male rats
Background and objectives: Berberis vulgaris L (Berberidaceae) is a medicinal plant that is distributed in different parts of Iran; it is grown as a wild or cultivated plant. It has different pharmacological activities such as antioxidant, anti-inflammatory, anti-arrhythmic, sedative and anti-malari...
| Format: | Article |
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| Langue: | English |
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Iranian Society of Pharmacognosy
2017-11-01
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| Collection: | Research Journal of Pharmacognosy |
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| Accès en ligne: | http://www.rjpharmacognosy.ir/article_53333_1f4f4d22f04d2c5e11c45007ef00c6c3.pdf |
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| collection | DOAJ |
| description | Background and objectives: Berberis vulgaris L (Berberidaceae) is a medicinal plant that is distributed in different parts of Iran; it is grown as a wild or cultivated plant. It has different pharmacological activities such as antioxidant, anti-inflammatory, anti-arrhythmic, sedative and anti-malaria effects. In this study, the anti-seizure activity of different fractions of this plant was evaluated. Methods: Seventy two rats were randomly divided in to nine groups (n=8 in each group). (1): negative control group (normal saline 10mL/kg), (2): positive control group (sodium valproate 1 mg/kg), (3, 4, 5): hydroalcoholic extract-treated groups (100, 200, 400 mg/kg), (6, 7): methanol fraction-treated groups (100 and 200 mg/kg) and (8, 9): chloroform fraction-treated group (100 and 200 mg/kg). Thirty minute after peritoneal injection of different doses of extract, fractions, saline and gavage of sodium valproate, PTZ (45 mg/kg) was injected and they were immediately transferred to a special cage, and the seizure parameters were evaluated for 30 min. Result: The injection of different doses of hydroalcoholic extract and different fractions had a dose-dependent effect on prolongation of latency to the onset of seizures. The effective dose was 400 mg/kg of hydroalcoholic extract and 200 mg/kg of methanol fraction. They decreased the rate of mortality and the number of suddenly seizures jumping significantly. Conclusion: The present study demonstrated that the hydroalcoholic extract and methanol fraction of B. vulgaris showed anticonvulsant activity in PTZ-induced seizures in mice. Therefore, this plant may be more useful in petit mal epilepsy. |
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| id | doaj.art-a0a8982d16ec4a34a61e2a85a0acaa77 |
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| issn | 2345-4458 2345-5977 |
| language | English |
| last_indexed | 2024-12-19T06:39:17Z |
| publishDate | 2017-11-01 |
| publisher | Iranian Society of Pharmacognosy |
| record_format | Article |
| series | Research Journal of Pharmacognosy |
| spelling | doaj.art-a0a8982d16ec4a34a61e2a85a0acaa772022-12-21T20:32:09ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772017-11-014Supplement10110153333Effects of Berberis vulgaris fractions on PTZ Induced seizure in male ratsBackground and objectives: Berberis vulgaris L (Berberidaceae) is a medicinal plant that is distributed in different parts of Iran; it is grown as a wild or cultivated plant. It has different pharmacological activities such as antioxidant, anti-inflammatory, anti-arrhythmic, sedative and anti-malaria effects. In this study, the anti-seizure activity of different fractions of this plant was evaluated. Methods: Seventy two rats were randomly divided in to nine groups (n=8 in each group). (1): negative control group (normal saline 10mL/kg), (2): positive control group (sodium valproate 1 mg/kg), (3, 4, 5): hydroalcoholic extract-treated groups (100, 200, 400 mg/kg), (6, 7): methanol fraction-treated groups (100 and 200 mg/kg) and (8, 9): chloroform fraction-treated group (100 and 200 mg/kg). Thirty minute after peritoneal injection of different doses of extract, fractions, saline and gavage of sodium valproate, PTZ (45 mg/kg) was injected and they were immediately transferred to a special cage, and the seizure parameters were evaluated for 30 min. Result: The injection of different doses of hydroalcoholic extract and different fractions had a dose-dependent effect on prolongation of latency to the onset of seizures. The effective dose was 400 mg/kg of hydroalcoholic extract and 200 mg/kg of methanol fraction. They decreased the rate of mortality and the number of suddenly seizures jumping significantly. Conclusion: The present study demonstrated that the hydroalcoholic extract and methanol fraction of B. vulgaris showed anticonvulsant activity in PTZ-induced seizures in mice. Therefore, this plant may be more useful in petit mal epilepsy.http://www.rjpharmacognosy.ir/article_53333_1f4f4d22f04d2c5e11c45007ef00c6c3.pdfBerberis vulgarisanti-seizures effectspentylenetetrazole |
| spellingShingle | Effects of Berberis vulgaris fractions on PTZ Induced seizure in male rats Research Journal of Pharmacognosy Berberis vulgaris anti-seizures effects pentylenetetrazole |
| title | Effects of Berberis vulgaris fractions on PTZ Induced seizure in male rats |
| title_full | Effects of Berberis vulgaris fractions on PTZ Induced seizure in male rats |
| title_fullStr | Effects of Berberis vulgaris fractions on PTZ Induced seizure in male rats |
| title_full_unstemmed | Effects of Berberis vulgaris fractions on PTZ Induced seizure in male rats |
| title_short | Effects of Berberis vulgaris fractions on PTZ Induced seizure in male rats |
| title_sort | effects of berberis vulgaris fractions on ptz induced seizure in male rats |
| topic | Berberis vulgaris anti-seizures effects pentylenetetrazole |
| url | http://www.rjpharmacognosy.ir/article_53333_1f4f4d22f04d2c5e11c45007ef00c6c3.pdf |