Interphase Cytogenetic Analysis of Micronucleated and Multinucleated Cells Supports the Premature Chromosome Condensation Hypothesis as the Mechanistic Origin of Chromothripsis
The discovery of chromothripsis in cancer genomes challenges the long-standing concept of carcinogenesis as the result of progressive genetic events. Despite recent advances in describing chromothripsis, its mechanistic origin remains elusive. The prevailing conception is that it arises from a massi...
Main Authors: | Antonio Pantelias, Ioanna Karachristou, Alexandros G. Georgakilas, Georgia I. Terzoudi |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-08-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/11/8/1123 |
Similar Items
-
Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering—A Critical Risk for Chromothripsis
by: Antonio Pantelias, et al.
Published: (2020-08-01) -
Chromothripsis—Explosion in Genetic Science
by: Mariia Shorokhova, et al.
Published: (2021-05-01) -
The genome sequence of Synechocystis sp. PCC 6803 substrain GT‐T and its implications for the evolution of PCC 6803 substrains
by: Satu Koskinen, et al.
Published: (2023-04-01) -
PCC Christmas Symposium Basel 2023
by: Gladwin Suryatin Alim, et al.
Published: (2024-03-01) -
Chromothripsis in lipoblastoma: second reported case with complex PLAG1 rearrangement
by: Joel Lanceta, et al.
Published: (2023-11-01)