Synthesis, Characterizations, and 9.4 Tesla T<sub>2</sub> MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles
Polyacrylic acid (PAA)-coated lanthanide oxide (Ln<sub>2</sub>O<sub>3</sub>) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T<sub>2</sub>) m...
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MDPI AG
2021-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/5/1355 |
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| author | Shanti Marasini Huan Yue Son Long Ho Ji Ae Park Soyeon Kim Ki-Hye Jung Hyunsil Cha Shuwen Liu Tirusew Tegafaw Mohammad Yaseen Ahmad Adibehalsadat Ghazanfari Kwon-Seok Chae Yongmin Chang Gang Ho Lee |
| author_facet | Shanti Marasini Huan Yue Son Long Ho Ji Ae Park Soyeon Kim Ki-Hye Jung Hyunsil Cha Shuwen Liu Tirusew Tegafaw Mohammad Yaseen Ahmad Adibehalsadat Ghazanfari Kwon-Seok Chae Yongmin Chang Gang Ho Lee |
| author_sort | Shanti Marasini |
| collection | DOAJ |
| description | Polyacrylic acid (PAA)-coated lanthanide oxide (Ln<sub>2</sub>O<sub>3</sub>) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T<sub>2</sub>) magnetic resonance imaging (MRI) contrast agents at high MR fields. Their r<sub>2</sub> values were appreciable at a 3.0 T MR field and higher at a 9.4 T MR field, whereas their r<sub>1</sub> values were negligible at all MR fields, indicating their exclusive induction of T<sub>2</sub> relaxations with negligible induction of T<sub>1</sub> relaxations. Their effectiveness as T<sub>2</sub> MRI contrast agents at high MR fields was confirmed from strong negative contrast enhancements in in vivo T<sub>2</sub> MR images at a 9.4 T MR field after intravenous administration into mice tails. |
| first_indexed | 2024-03-10T11:13:28Z |
| format | Article |
| id | doaj.art-a0aa936ee2f74e86a32676a123bea39a |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T11:13:28Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-a0aa936ee2f74e86a32676a123bea39a2023-11-21T20:38:13ZengMDPI AGNanomaterials2079-49912021-05-01115135510.3390/nano11051355Synthesis, Characterizations, and 9.4 Tesla T<sub>2</sub> MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide NanoparticlesShanti Marasini0Huan Yue1Son Long Ho2Ji Ae Park3Soyeon Kim4Ki-Hye Jung5Hyunsil Cha6Shuwen Liu7Tirusew Tegafaw8Mohammad Yaseen Ahmad9Adibehalsadat Ghazanfari10Kwon-Seok Chae11Yongmin Chang12Gang Ho Lee13Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, KoreaDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, KoreaDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, KoreaDivision of RI-Convergence Research, Korea Institute of Radiological and Medical Science (KIRAMS), Seoul 01817, KoreaDivision of RI-Convergence Research, Korea Institute of Radiological and Medical Science (KIRAMS), Seoul 01817, KoreaMedical Device-Bio Research Institute, Korea Testing and Research Institute, Gwacheon 13810, KoreaDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, KoreaDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, KoreaDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, KoreaDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, KoreaDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, KoreaDepartment of Biology Education, Teacher’s College, Kyungpook National University, Taegu 41566, KoreaDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, KoreaDepartment of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, KoreaPolyacrylic acid (PAA)-coated lanthanide oxide (Ln<sub>2</sub>O<sub>3</sub>) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T<sub>2</sub>) magnetic resonance imaging (MRI) contrast agents at high MR fields. Their r<sub>2</sub> values were appreciable at a 3.0 T MR field and higher at a 9.4 T MR field, whereas their r<sub>1</sub> values were negligible at all MR fields, indicating their exclusive induction of T<sub>2</sub> relaxations with negligible induction of T<sub>1</sub> relaxations. Their effectiveness as T<sub>2</sub> MRI contrast agents at high MR fields was confirmed from strong negative contrast enhancements in in vivo T<sub>2</sub> MR images at a 9.4 T MR field after intravenous administration into mice tails.https://www.mdpi.com/2079-4991/11/5/1355Tb<sub>2</sub>O<sub>3</sub>Ho<sub>2</sub>O<sub>3</sub>nanoparticlespolyacrylic acid-coatinghigh MR fieldMRI |
| spellingShingle | Shanti Marasini Huan Yue Son Long Ho Ji Ae Park Soyeon Kim Ki-Hye Jung Hyunsil Cha Shuwen Liu Tirusew Tegafaw Mohammad Yaseen Ahmad Adibehalsadat Ghazanfari Kwon-Seok Chae Yongmin Chang Gang Ho Lee Synthesis, Characterizations, and 9.4 Tesla T<sub>2</sub> MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles Nanomaterials Tb<sub>2</sub>O<sub>3</sub> Ho<sub>2</sub>O<sub>3</sub> nanoparticles polyacrylic acid-coating high MR field MRI |
| title | Synthesis, Characterizations, and 9.4 Tesla T<sub>2</sub> MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles |
| title_full | Synthesis, Characterizations, and 9.4 Tesla T<sub>2</sub> MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles |
| title_fullStr | Synthesis, Characterizations, and 9.4 Tesla T<sub>2</sub> MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles |
| title_full_unstemmed | Synthesis, Characterizations, and 9.4 Tesla T<sub>2</sub> MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles |
| title_short | Synthesis, Characterizations, and 9.4 Tesla T<sub>2</sub> MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles |
| title_sort | synthesis characterizations and 9 4 tesla t sub 2 sub mr images of polyacrylic acid coated terbium iii and holmium iii oxide nanoparticles |
| topic | Tb<sub>2</sub>O<sub>3</sub> Ho<sub>2</sub>O<sub>3</sub> nanoparticles polyacrylic acid-coating high MR field MRI |
| url | https://www.mdpi.com/2079-4991/11/5/1355 |
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