Levodopa Improves Behavioral Deficits of Mice with Parkinson's Disease Symptoms via Curbing NLRP3 Inflammasome Activation and Enhancing Tyrosine Hydroxylase Levels in the Striatum and Substantia Nigra

Levodopa Improves Behavioral Deficits of Mice with Parkinson's Disease Symptoms via Curbing NLRP3 Inflammasome Activation and Enhancing Tyrosine Hydroxylase Levels in the Striatum and Substantia Nigra

Objective: Levodopa (L-DOPA) is the primary treatment for Parkinson’s disease (PD). Nevertheless, the underlying mechanism of its action is not entirely learned. This study aims to probe the action of L-DOPA on NLR pyrin domain containing 3 (NLRP3) inflammasome activation and tyrosine hydroxylase (T...

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Bibliographic Details
Main Authors: Xi Chen, Zhao Wang, Weihua Yang, Yuejun Fu
Format: Article
Language:English
Published: IMR Press 2024-01-01
Series:Journal of Integrative Neuroscience
Subjects:
parkinson's disease
levodopa
substantia nigra
striatum
nlrp3
tyrosine hydroxylase
Online Access:https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301002

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