Metabolic Syndrome Is Associated with Poor Omicron Infection Prognosis While Inactivated Vaccine Improves the Outcome of Coronavirus Disease 2019 among Chinese Inhabitants: A Retrospective Observational Study from a Chinese Municipality
Coronavirus disease 2019 (COVID-19) and metabolic syndrome (MetS) are currently highly prevalent diseases worldwide. Studies on clinical outcomes of patients with Omicron and MetS, especially after vaccination with an inactivated vaccine are limited. Herein, we explored the relationship between MetS...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/10/1554 |
| _version_ | 1797572127099977728 |
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| author | Ying Liu Dong Chen Junfeng Li Wei Wang Rongfeng Han Shanshan Cui Suqing Bao |
| author_facet | Ying Liu Dong Chen Junfeng Li Wei Wang Rongfeng Han Shanshan Cui Suqing Bao |
| author_sort | Ying Liu |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) and metabolic syndrome (MetS) are currently highly prevalent diseases worldwide. Studies on clinical outcomes of patients with Omicron and MetS, especially after vaccination with an inactivated vaccine are limited. Herein, we explored the relationship between MetS and the outcome of Omicron infection. Study Design: This was a retrospective observational study. Methods: This study recruited 316 individuals with Omicron infection. The inpatient data from between 8 January and 7 February 2022 were obtained from designated isolation hospitals in Tianjin, China. Hierarchical and multivariable analysis was conducted on age, gender, number of complications, and vaccination status. Results: Among the 316 study participants, 35.1% were diagnosed with MetS. The results showed that MetS was strongly associated with Intensive Unit Care (ICU) admission, Polymerase Chain Reaction (PCR) re-positivity, and severe COVID-19. The ICU admission rates of the unvaccinated individuals, those who received two-dose and full vaccination (3 doses), were 66.7%, 19.2%, and 0, respectively (<i>p</i> < 0.01). Two-dose and three-dose vaccinations significantly reduced PCR re-positivity. Conclusions: In summary, MetS increases the risk of ICU admission, PCR re-positivity, and severe COVID-19. MetS is a composite predictor of poor outcomes of Omicron infection. Two shots of inactivated vaccine, specifically three doses, effectively protect against Omicron even in the high-risk group. |
| first_indexed | 2024-03-10T20:50:05Z |
| format | Article |
| id | doaj.art-a0ab0ee88eaf47478227fda694d97a6f |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T20:50:05Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-a0ab0ee88eaf47478227fda694d97a6f2023-11-19T18:24:27ZengMDPI AGVaccines2076-393X2023-09-011110155410.3390/vaccines11101554Metabolic Syndrome Is Associated with Poor Omicron Infection Prognosis While Inactivated Vaccine Improves the Outcome of Coronavirus Disease 2019 among Chinese Inhabitants: A Retrospective Observational Study from a Chinese MunicipalityYing Liu0Dong Chen1Junfeng Li2Wei Wang3Rongfeng Han4Shanshan Cui5Suqing Bao6Endocrinology Department, Tianjin First Central Hospital, Nankai University, Tianjin 300192, ChinaGraduate School, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, ChinaEndocrinology Department, Tianjin First Central Hospital, Nankai University, Tianjin 300192, ChinaEndocrinology Department, Tianjin First Central Hospital, Nankai University, Tianjin 300192, ChinaEndocrinology Department, Tianjin First Central Hospital, Nankai University, Tianjin 300192, ChinaEndocrinology Department, Tianjin First Central Hospital, Nankai University, Tianjin 300192, ChinaEndocrinology Department, Tianjin First Central Hospital, Nankai University, Tianjin 300192, ChinaCoronavirus disease 2019 (COVID-19) and metabolic syndrome (MetS) are currently highly prevalent diseases worldwide. Studies on clinical outcomes of patients with Omicron and MetS, especially after vaccination with an inactivated vaccine are limited. Herein, we explored the relationship between MetS and the outcome of Omicron infection. Study Design: This was a retrospective observational study. Methods: This study recruited 316 individuals with Omicron infection. The inpatient data from between 8 January and 7 February 2022 were obtained from designated isolation hospitals in Tianjin, China. Hierarchical and multivariable analysis was conducted on age, gender, number of complications, and vaccination status. Results: Among the 316 study participants, 35.1% were diagnosed with MetS. The results showed that MetS was strongly associated with Intensive Unit Care (ICU) admission, Polymerase Chain Reaction (PCR) re-positivity, and severe COVID-19. The ICU admission rates of the unvaccinated individuals, those who received two-dose and full vaccination (3 doses), were 66.7%, 19.2%, and 0, respectively (<i>p</i> < 0.01). Two-dose and three-dose vaccinations significantly reduced PCR re-positivity. Conclusions: In summary, MetS increases the risk of ICU admission, PCR re-positivity, and severe COVID-19. MetS is a composite predictor of poor outcomes of Omicron infection. Two shots of inactivated vaccine, specifically three doses, effectively protect against Omicron even in the high-risk group.https://www.mdpi.com/2076-393X/11/10/1554COVID-19OmicronMetSCOVID-19 severityinactivated vaccines |
| spellingShingle | Ying Liu Dong Chen Junfeng Li Wei Wang Rongfeng Han Shanshan Cui Suqing Bao Metabolic Syndrome Is Associated with Poor Omicron Infection Prognosis While Inactivated Vaccine Improves the Outcome of Coronavirus Disease 2019 among Chinese Inhabitants: A Retrospective Observational Study from a Chinese Municipality Vaccines COVID-19 Omicron MetS COVID-19 severity inactivated vaccines |
| title | Metabolic Syndrome Is Associated with Poor Omicron Infection Prognosis While Inactivated Vaccine Improves the Outcome of Coronavirus Disease 2019 among Chinese Inhabitants: A Retrospective Observational Study from a Chinese Municipality |
| title_full | Metabolic Syndrome Is Associated with Poor Omicron Infection Prognosis While Inactivated Vaccine Improves the Outcome of Coronavirus Disease 2019 among Chinese Inhabitants: A Retrospective Observational Study from a Chinese Municipality |
| title_fullStr | Metabolic Syndrome Is Associated with Poor Omicron Infection Prognosis While Inactivated Vaccine Improves the Outcome of Coronavirus Disease 2019 among Chinese Inhabitants: A Retrospective Observational Study from a Chinese Municipality |
| title_full_unstemmed | Metabolic Syndrome Is Associated with Poor Omicron Infection Prognosis While Inactivated Vaccine Improves the Outcome of Coronavirus Disease 2019 among Chinese Inhabitants: A Retrospective Observational Study from a Chinese Municipality |
| title_short | Metabolic Syndrome Is Associated with Poor Omicron Infection Prognosis While Inactivated Vaccine Improves the Outcome of Coronavirus Disease 2019 among Chinese Inhabitants: A Retrospective Observational Study from a Chinese Municipality |
| title_sort | metabolic syndrome is associated with poor omicron infection prognosis while inactivated vaccine improves the outcome of coronavirus disease 2019 among chinese inhabitants a retrospective observational study from a chinese municipality |
| topic | COVID-19 Omicron MetS COVID-19 severity inactivated vaccines |
| url | https://www.mdpi.com/2076-393X/11/10/1554 |
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