AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS
Background: Amyotrophic lateral sclerosis (ALS) is a rare chronic degenerative disease. The only approved treatment, Riluzole, is not available and is not economically affordable for most patients. Objective: To report here a case of a pregnant woman 27 years of age with ALS, confirmed through el...
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2021-07-01
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| Series: | Malang Neurology Journal |
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| Online Access: | https://mnj.ub.ac.id/index.php/mnj/article/view/548 |
| _version_ | 1818569372664332288 |
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| author | David Uriel Ayllón Álvarez Mariana Neri Calixto César Humberto Aparicio Albarrán Hugo Mendieta Zerón |
| author_facet | David Uriel Ayllón Álvarez Mariana Neri Calixto César Humberto Aparicio Albarrán Hugo Mendieta Zerón |
| author_sort | David Uriel Ayllón Álvarez |
| collection | DOAJ |
| description | Background: Amyotrophic lateral sclerosis (ALS) is a rare chronic degenerative disease. The only approved treatment, Riluzole, is not available and is not economically affordable for most patients.
Objective: To report here a case of a pregnant woman 27 years of age with ALS, confirmed through electromyography. After spontaneous abortion and 88 days without clinical improvement and dependent on mechanical ventilation, treatment with autologous stem cell transplantation and immunomodulation was decided upon for the patient.
Methods: The patient received a daily subcutaneous (s.c.) dose of 300 μg human Granulocyte-Colony stimulating factor for a period of 3 days. Peripheral blood mononuclear cells were isolated by leukapheresis. These cells were self-transplanted to the patient 5 cc via lumbar puncture and 5 cc intravenously (i.v.). The immunomodulation treatment was based on the surface-fixation method.
Results: The patient remained hospitalized for an additional 249 days, at which time when she was contrareferred to a secondary-level health institution.
Conclusion: A treatment scheme combining ASCT (Autologous Stem Cell Transplantation) and immunomodulation, based on the surface-fixation method, could be an option to get a large period of no progression stage in ALS. |
| first_indexed | 2024-12-14T06:47:16Z |
| format | Article |
| id | doaj.art-a0b0fe17bec94c87a977d434461622a3 |
| institution | Directory Open Access Journal |
| issn | 2407-6724 2442-5001 |
| language | English |
| last_indexed | 2024-12-14T06:47:16Z |
| publishDate | 2021-07-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Malang Neurology Journal |
| spelling | doaj.art-a0b0fe17bec94c87a977d434461622a32022-12-21T23:13:00ZengUniversity of BrawijayaMalang Neurology Journal2407-67242442-50012021-07-017214014510.21776/ub.mnj.2021.007.02.12AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSISDavid Uriel Ayllón Álvarez0Mariana Neri Calixto1César Humberto Aparicio Albarrán2Hugo Mendieta Zerón3Faculty of Medicine, Autonomous University of the State of Mexico, Toluca, Mexico State, MexicoFaculty of Medicine, Autonomous University of the State of Mexico, Toluca, Mexico State, MexicoISSSTE Hospital General Toluca, Mexico.Faculty of Medicine, Autonomous University of the State of Mexico and Mónica Pretelini Sáenz Maternal-Perinatal Hospital, Toluca, Mexico State, MexicoBackground: Amyotrophic lateral sclerosis (ALS) is a rare chronic degenerative disease. The only approved treatment, Riluzole, is not available and is not economically affordable for most patients. Objective: To report here a case of a pregnant woman 27 years of age with ALS, confirmed through electromyography. After spontaneous abortion and 88 days without clinical improvement and dependent on mechanical ventilation, treatment with autologous stem cell transplantation and immunomodulation was decided upon for the patient. Methods: The patient received a daily subcutaneous (s.c.) dose of 300 μg human Granulocyte-Colony stimulating factor for a period of 3 days. Peripheral blood mononuclear cells were isolated by leukapheresis. These cells were self-transplanted to the patient 5 cc via lumbar puncture and 5 cc intravenously (i.v.). The immunomodulation treatment was based on the surface-fixation method. Results: The patient remained hospitalized for an additional 249 days, at which time when she was contrareferred to a secondary-level health institution. Conclusion: A treatment scheme combining ASCT (Autologous Stem Cell Transplantation) and immunomodulation, based on the surface-fixation method, could be an option to get a large period of no progression stage in ALS.https://mnj.ub.ac.id/index.php/mnj/article/view/548amyotrophic lateral sclerosisautologous stem cell transplantationpuerperiumsurface-fixation method |
| spellingShingle | David Uriel Ayllón Álvarez Mariana Neri Calixto César Humberto Aparicio Albarrán Hugo Mendieta Zerón AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS Malang Neurology Journal amyotrophic lateral sclerosis autologous stem cell transplantation puerperium surface-fixation method |
| title | AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS |
| title_full | AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS |
| title_fullStr | AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS |
| title_full_unstemmed | AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS |
| title_short | AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS |
| title_sort | autologous stem cell transplantation and immunomodulation in amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis autologous stem cell transplantation puerperium surface-fixation method |
| url | https://mnj.ub.ac.id/index.php/mnj/article/view/548 |
| work_keys_str_mv | AT davidurielayllonalvarez autologousstemcelltransplantationandimmunomodulationinamyotrophiclateralsclerosis AT mariananericalixto autologousstemcelltransplantationandimmunomodulationinamyotrophiclateralsclerosis AT cesarhumbertoaparicioalbarran autologousstemcelltransplantationandimmunomodulationinamyotrophiclateralsclerosis AT hugomendietazeron autologousstemcelltransplantationandimmunomodulationinamyotrophiclateralsclerosis |