Evaluation of antihyperglycemic activity of aqueous stem bark extract of Boswellia dalzielii in alloxan-induced diabetic Wistar rats
Abstract Background Diabetes mellitus is one of the leading causes of morbidity and mortality globally. Although synthetic hypoglycemic agents are commonly used to manage this disorder, such medications, besides being unable to cure the disease, are expensive and associated with side effects. Conver...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-01-01
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| Series: | Future Journal of Pharmaceutical Sciences |
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| Online Access: | https://doi.org/10.1186/s43094-023-00458-4 |
| _version_ | 1811175954009030656 |
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| author | Ahmad Alhassan Ibrahim Muhammed Sani Abdussalami Joseph Appah Abdullahi Hussein Umar Amina Umar Muhammad Sani Haruna Aminu Alhassan Ibrahim |
| author_facet | Ahmad Alhassan Ibrahim Muhammed Sani Abdussalami Joseph Appah Abdullahi Hussein Umar Amina Umar Muhammad Sani Haruna Aminu Alhassan Ibrahim |
| author_sort | Ahmad Alhassan Ibrahim |
| collection | DOAJ |
| description | Abstract Background Diabetes mellitus is one of the leading causes of morbidity and mortality globally. Although synthetic hypoglycemic agents are commonly used to manage this disorder, such medications, besides being unable to cure the disease, are expensive and associated with side effects. Conversely, medicinal plants have emerged as effective, safe and affordable alternative treatments. Boswellia dalzielii plant has been reported to possess ethnomedicinal properties for the treatment of various health conditions; however, scientific studies exploring this plant as antihyperglycemic agent are still limited. Thus, this study evaluated the antihyperglycemic activity of aqueous stem bark extract (ASBE) of B. dalzielii in alloxan-induced diabetic Wistar albino rats. Methods Phytochemical screening of the ASBE of B. dalzielii was conducted. Twenty male Wistar albino rats weighing 100–150 g divided into 4 groups (A–D) of five rats were used for the study. Group A served as the normal control and received neither ASBE of B. dalzielii nor glibenclamide. The treatment for the other three groups was as follows: Group B, 10 mg/kg of glibenclamide (diabetic control); Group C, 500 mg/kg ASBE of B. dalzielii; and Group D, 1000 mg/kg ASBE of B. dalzielii. Treatments were administered orally every 24 h for a period of 2 weeks. Blood glucose level and body weight were evaluated at weeks 0, 1 and 2. Histomorphological features of the rats’ pancreas in all the groups were compared. Results The phytochemical analysis revealed the presence of alkaloids, saponins, tannins, cardiac glycosides, flavonoids, carbohydrates, steroids and triterpenes. The two different doses of the plant extract significantly reduced blood glucose level at weeks 1 and 2 (all p < 0.05), with the 1000 mg/kg dose demonstrating a greater reduction compared with glibenclamide at week 2 (p = 0.014). However, only the 500 mg/kg dose led to restoration, albeit slight, of the pancreatic islet cells. Conclusion This study suggests that B. dalzielii plant exhibits a potent antihyperglycemic activity evidenced by reduced blood glucose levels and slight restoration of pancreatic islet cells. This plant could be, therefore, considered in the treatment of diabetes mellitus. Graphical Abstract |
| first_indexed | 2024-04-10T19:45:27Z |
| format | Article |
| id | doaj.art-a0b2a7248dd94c8d9f297e5bc3a86a47 |
| institution | Directory Open Access Journal |
| issn | 2314-7253 |
| language | English |
| last_indexed | 2024-04-10T19:45:27Z |
| publishDate | 2023-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-a0b2a7248dd94c8d9f297e5bc3a86a472023-01-29T12:06:19ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532023-01-019111010.1186/s43094-023-00458-4Evaluation of antihyperglycemic activity of aqueous stem bark extract of Boswellia dalzielii in alloxan-induced diabetic Wistar ratsAhmad Alhassan Ibrahim0Muhammed Sani Abdussalami1Joseph Appah2Abdullahi Hussein Umar3Amina Umar Muhammad4Sani Haruna5Aminu Alhassan Ibrahim6Department of Crop Production Technology, Audu Bako College of Agriculture DambattaDepartment of Biological Sciences, Faculty of Science, Nigerian Defence AcademyDepartment of Biological Sciences, Faculty of Science, Nigerian Defence AcademyDepartment of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello UniversityDepartment of Remedial and General Studies, Audu Bako College of Agriculture DambattaDepartment of Forestry Technology, Audu Bako College of Agriculture DambattaDepartment of Physiotherapy, School of Basic Medical Sciences, Skyline University NigeriaAbstract Background Diabetes mellitus is one of the leading causes of morbidity and mortality globally. Although synthetic hypoglycemic agents are commonly used to manage this disorder, such medications, besides being unable to cure the disease, are expensive and associated with side effects. Conversely, medicinal plants have emerged as effective, safe and affordable alternative treatments. Boswellia dalzielii plant has been reported to possess ethnomedicinal properties for the treatment of various health conditions; however, scientific studies exploring this plant as antihyperglycemic agent are still limited. Thus, this study evaluated the antihyperglycemic activity of aqueous stem bark extract (ASBE) of B. dalzielii in alloxan-induced diabetic Wistar albino rats. Methods Phytochemical screening of the ASBE of B. dalzielii was conducted. Twenty male Wistar albino rats weighing 100–150 g divided into 4 groups (A–D) of five rats were used for the study. Group A served as the normal control and received neither ASBE of B. dalzielii nor glibenclamide. The treatment for the other three groups was as follows: Group B, 10 mg/kg of glibenclamide (diabetic control); Group C, 500 mg/kg ASBE of B. dalzielii; and Group D, 1000 mg/kg ASBE of B. dalzielii. Treatments were administered orally every 24 h for a period of 2 weeks. Blood glucose level and body weight were evaluated at weeks 0, 1 and 2. Histomorphological features of the rats’ pancreas in all the groups were compared. Results The phytochemical analysis revealed the presence of alkaloids, saponins, tannins, cardiac glycosides, flavonoids, carbohydrates, steroids and triterpenes. The two different doses of the plant extract significantly reduced blood glucose level at weeks 1 and 2 (all p < 0.05), with the 1000 mg/kg dose demonstrating a greater reduction compared with glibenclamide at week 2 (p = 0.014). However, only the 500 mg/kg dose led to restoration, albeit slight, of the pancreatic islet cells. Conclusion This study suggests that B. dalzielii plant exhibits a potent antihyperglycemic activity evidenced by reduced blood glucose levels and slight restoration of pancreatic islet cells. This plant could be, therefore, considered in the treatment of diabetes mellitus. Graphical Abstracthttps://doi.org/10.1186/s43094-023-00458-4AlloxanBlood glucose levelsBoswellia dalzieliiDiabetes mellitusHypoglycemia |
| spellingShingle | Ahmad Alhassan Ibrahim Muhammed Sani Abdussalami Joseph Appah Abdullahi Hussein Umar Amina Umar Muhammad Sani Haruna Aminu Alhassan Ibrahim Evaluation of antihyperglycemic activity of aqueous stem bark extract of Boswellia dalzielii in alloxan-induced diabetic Wistar rats Future Journal of Pharmaceutical Sciences Alloxan Blood glucose levels Boswellia dalzielii Diabetes mellitus Hypoglycemia |
| title | Evaluation of antihyperglycemic activity of aqueous stem bark extract of Boswellia dalzielii in alloxan-induced diabetic Wistar rats |
| title_full | Evaluation of antihyperglycemic activity of aqueous stem bark extract of Boswellia dalzielii in alloxan-induced diabetic Wistar rats |
| title_fullStr | Evaluation of antihyperglycemic activity of aqueous stem bark extract of Boswellia dalzielii in alloxan-induced diabetic Wistar rats |
| title_full_unstemmed | Evaluation of antihyperglycemic activity of aqueous stem bark extract of Boswellia dalzielii in alloxan-induced diabetic Wistar rats |
| title_short | Evaluation of antihyperglycemic activity of aqueous stem bark extract of Boswellia dalzielii in alloxan-induced diabetic Wistar rats |
| title_sort | evaluation of antihyperglycemic activity of aqueous stem bark extract of boswellia dalzielii in alloxan induced diabetic wistar rats |
| topic | Alloxan Blood glucose levels Boswellia dalzielii Diabetes mellitus Hypoglycemia |
| url | https://doi.org/10.1186/s43094-023-00458-4 |
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