Does lipopolysaccharide-based neuroinflammation induce microglia polarization?
Lipopolysaccharide (LPS) is a potent immunogen when administered locally and/or systemically. The peripheral immunization with LPS could contribute to the progression of neurological diseases because a strong link between neuroinflammation and dopaminergic degeneration has been found. The switch bet...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2020-06-01
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| Series: | Folia Neuropathologica |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Does-lipopolysaccharide-based-neuroinflammation-induce-microglia-polarization-,20,41106,1,1.html |
| _version_ | 1818588932989779968 |
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| author | Daniel Hernandez Baltazar Rasajna Nadella Abril Barrientos Bonilla Yazmin Flores Martínez Abraham Olguín Paola Heman Bozadas María Rovirosa Hernández Iliana Cibrián Llanderal |
| author_facet | Daniel Hernandez Baltazar Rasajna Nadella Abril Barrientos Bonilla Yazmin Flores Martínez Abraham Olguín Paola Heman Bozadas María Rovirosa Hernández Iliana Cibrián Llanderal |
| author_sort | Daniel Hernandez Baltazar |
| collection | DOAJ |
| description | Lipopolysaccharide (LPS) is a potent immunogen when administered locally and/or systemically. The peripheral immunization with LPS could contribute to the progression of neurological diseases because a strong link between neuroinflammation and dopaminergic degeneration has been found. The switch between the survival and neuronal death in substantia nigra could be related to M1 (neurotoxic) and M2 (neuroprotective) microglia phenotypes. In this review, we present the current findings about microglia roles, biomarkers, and natural or synthetic immune modulators determined in the LPS-based murine model. |
| first_indexed | 2024-12-16T09:32:37Z |
| format | Article |
| id | doaj.art-a0b3be081c4f4acdb3690f65dbc5b2dc |
| institution | Directory Open Access Journal |
| issn | 1641-4640 1509-572X |
| language | English |
| last_indexed | 2024-12-16T09:32:37Z |
| publishDate | 2020-06-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Folia Neuropathologica |
| spelling | doaj.art-a0b3be081c4f4acdb3690f65dbc5b2dc2022-12-21T22:36:29ZengTermedia Publishing HouseFolia Neuropathologica1641-46401509-572X2020-06-0158211312210.5114/fn.2020.9675541106Does lipopolysaccharide-based neuroinflammation induce microglia polarization?Daniel Hernandez BaltazarRasajna NadellaAbril Barrientos BonillaYazmin Flores MartínezAbraham OlguínPaola Heman BozadasMaría Rovirosa HernándezIliana Cibrián LlanderalLipopolysaccharide (LPS) is a potent immunogen when administered locally and/or systemically. The peripheral immunization with LPS could contribute to the progression of neurological diseases because a strong link between neuroinflammation and dopaminergic degeneration has been found. The switch between the survival and neuronal death in substantia nigra could be related to M1 (neurotoxic) and M2 (neuroprotective) microglia phenotypes. In this review, we present the current findings about microglia roles, biomarkers, and natural or synthetic immune modulators determined in the LPS-based murine model.https://www.termedia.pl/Does-lipopolysaccharide-based-neuroinflammation-induce-microglia-polarization-,20,41106,1,1.htmlcell signalling lipopolysaccharide proliferation microglia cells neuroinflammation. |
| spellingShingle | Daniel Hernandez Baltazar Rasajna Nadella Abril Barrientos Bonilla Yazmin Flores Martínez Abraham Olguín Paola Heman Bozadas María Rovirosa Hernández Iliana Cibrián Llanderal Does lipopolysaccharide-based neuroinflammation induce microglia polarization? Folia Neuropathologica cell signalling lipopolysaccharide proliferation microglia cells neuroinflammation. |
| title | Does lipopolysaccharide-based neuroinflammation induce microglia polarization? |
| title_full | Does lipopolysaccharide-based neuroinflammation induce microglia polarization? |
| title_fullStr | Does lipopolysaccharide-based neuroinflammation induce microglia polarization? |
| title_full_unstemmed | Does lipopolysaccharide-based neuroinflammation induce microglia polarization? |
| title_short | Does lipopolysaccharide-based neuroinflammation induce microglia polarization? |
| title_sort | does lipopolysaccharide based neuroinflammation induce microglia polarization |
| topic | cell signalling lipopolysaccharide proliferation microglia cells neuroinflammation. |
| url | https://www.termedia.pl/Does-lipopolysaccharide-based-neuroinflammation-induce-microglia-polarization-,20,41106,1,1.html |
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