Human genetic analyses of organelles highlight the nucleus in age-related trait heritability
Most age-related human diseases are accompanied by a decline in cellular organelle integrity, including impaired lysosomal proteostasis and defective mitochondrial oxidative phosphorylation. An open question, however, is the degree to which inherited variation in or near genes encoding each organell...
Main Authors: | Rahul Gupta, Konrad J Karczewski, Daniel Howrigan, Benjamin M Neale, Vamsi K Mootha |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-09-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/68610 |
Similar Items
-
Editorial: Energy-producing organelles and the nucleus: a phenomenal genomic friendship
by: Dmytro V. Gospodaryov, et al.
Published: (2023-06-01) -
Independent organelle and organelle—organelle interactions: essential mechanisms for malignant gynecological cancer cell survival
by: Ying Shen, et al.
Published: (2024-04-01) -
Mitochondria inter-organelle relationships in cancer protein aggregation
by: Ilaria Genovese, et al.
Published: (2022-12-01) -
Tubular extensions of plant organelles and their implications on retrograde signaling
by: Ryuuichi Itoh
Published: (2023-11-01) -
Organelle Membrane Extensions in Mammalian Cells
by: Ruth E. Carmichael, et al.
Published: (2023-04-01)